{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:06:34Z","timestamp":1760141194680,"version":"build-2065373602"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,9,18]],"date-time":"2006-09-18T00:00:00Z","timestamp":1158537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the anti\u2010inflammatory effects of caffeic acid phenethyl ester (CAPE), a natural bee\u2010produced compound, and compared it with corticosteroids in the treatment of experimentally induced methicillin\u2010resistant <jats:italic>Staphylococcus epidermidis<\/jats:italic> (MRSE) endophthalmitis in addition to intravitreal antibiotics. An experimental endophthalmitis model was produced in 24 New Zealand albino rabbits by unilateral intravitreal injection of 0.1\u2009ml of 4.7\u2009\u00d7\u200910<jats:sup>4<\/jats:sup> colony\u2010forming units (CFU) methicillin\u2010resistant <jats:italic>S. epidermidis<\/jats:italic>. The animals were then divided randomly into three treatment groups and a control group, group 1 (six rabbits), received only intravitreal vancomycin (1.0\u2009mg\/0.1\u2009ml); group 2 (six rabbits), received both intravitreal vancomycin (1.0\u2009mg\/0.1\u2009ml) and intravitreal dexamethasone (400\u2009\u00b5g\/0.1\u2009ml) and group 3 (six rabbits), received both intravitreal vancomycin (1.0\u2009mg\/0.1\u2009ml) and subtenon CAPE (10\u2009mg\/0.3\u2009ml) after 24\u2009h post\u2010infection. No treatment was given to the control group. Treatment efficacy was assessed by clinical examination, vitreous culture and histopathology. There were no statististically significant differences between clinical scores of all groups in examinations at 24 and 48\u2009h post\u2010infection (<jats:italic>p<\/jats:italic>\u2009=\u20090.915 and <jats:italic>p<\/jats:italic>\u2009=\u20090.067 respectively), but in examinations at 72\u2009h post\u2010infection and after 7 days post\u2010infection, although the clinical scores of treatment groups were not significantly different from each other, they were significantly lower than the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The culture results of all groups were sterile. As a result, CAPE was found to be as effective as dexamethasone in reducing inflammation in the treatment of experimental MRSE endophthalmitis when used with antibiotics. More studies are needed to determine the optimal administration route and effective dosage of this compound. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.1377","type":"journal-article","created":{"date-parts":[[2006,9,18]],"date-time":"2006-09-18T06:24:24Z","timestamp":1158560664000},"page":"693-700","source":"Crossref","is-referenced-by-count":7,"title":["Effect of caffeic acid phenethyl ester on treatment of experimentally induced methicillin\u2010resi\u0307stant <i>Staphylococcus epidermidis<\/i> endophthalmitis in a rabbit 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