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Rats were randomly divided into four groups as control (corn oil), dichlorvos (30\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> i.p.), 1 and 10\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> Y\u201027632\u2009+\u2009dichlorvos groups. Cholinergic signs (fatigue, tremor, cyanosis, hyper\u2010secretion, fasciculations) were observed in all the rats in the dichlorvos group and the mortality rate was 50%. No cholinergic findings and deaths were observed in the control and Y\u201027632 groups. Plasma cholinesterase activities were suppressed with dichlorvos and these reductions were attenuated with Y\u201027632 pretreatment. There was a marked increase in plasma malondialdehyde level in the dichlorvos group, but Y\u201027632 pretreatment abolished this elevation. Dichlorvos markedly depressed cardiac paraoxonase activity, but these changes were not markedly modified with Y\u201027632. Total antioxidant capacities, total oxidant status, oxidative stress index, total free sulfhydryl groups and catalase activities in plasma and cardiac tissues were not markedly different between the groups. No significant changes were observed with cardiac myeloperoxidase activities or plasma arylesterase and ceruloplasmin activities. In conclusion, our results suggest that Rho\u2010kinase pathway is involved in organophosphate intoxication, and a decrease in cardiac paraoxonase activities may play a role in the pathogenesis of acute organophosphate poisoning in rats. 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