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The aim of this study is to determine collagen levels and the gelatinase activities in tissue from hypertrophic scars, atrophic scars, keloids and donor skin in 36 patients and 14 donors. Gelatinase levels (proenzyme\u2009+\u2009active enzyme) were determined by ELISA and their activities by gelatin zymography. MMP\u20109 activity was undetectable in gelatin zymography analysis. Pro\u2010MMP\u20102 levels (median) were highest in normal skin group 53.58 (36.40\u201375.11) OD\u2009\u00b5g<jats:sup>\u22121<\/jats:sup> protein, while active MMP\u20102 levels were highest in keloid group 52.53 (42.47\u201361.51) OD\u2009\u00b5g<jats:sup>\u22121<\/jats:sup> protein. The active\/pro ratio was the highest in keloid group 0.97 followed by hypertrophic scar, normal skin and atrophic scar groups 0.69\u2009&gt;\u20090.54\u2009&gt;\u20090.48, respectively. According to results of our study, the two\u2010phase theory of the duration of hypertrophic scar and keloid formation can be supported by the data of tissue collagen and gelatinase analysis. This study is the first to relate scar formation relationship in regard to gelatinase activation ratio in a keloid, hypertrophic and atrophic scar patient group which is chosen appropriate in age and sex. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.1537","type":"journal-article","created":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T06:10:42Z","timestamp":1232604642000},"page":"81-87","source":"Crossref","is-referenced-by-count":41,"title":["Matrix metalloproteinase\u20102 and \u20109 activities in human keloids, hypertrophic and atrophic scars: a pilot 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