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This study was designed to investigate the effect of PD\u20101 extract in the Parkinson's model of 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP) lesioned mice. The MPTP administration caused the dopamine neuron loss in the striatum and substantia nigra pars compacta (SNpc), which was demonstrated by a depletion of tyrosine hydroxylase (TH). In addition, a reduction of bcl\u20102 expression with elevation of bax expression, caspase\u20103 activation, and release of cytochrome <jats:italic>c<\/jats:italic> into cytosol in dopaminergic neurons of SNpc were noted. Oral administration of PD\u20101 extract (50 and 100\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>) attenuated the MPTP\u2010induced depletion of TH proteins in the striatum and SNpc and prevented the apoptotic effects. These results indicate that PD\u20101 extract is able to protect dopaminergic neurons from MPTP\u2010induced neuronal death, with important implications for the treatment of PD. 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