{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:14:30Z","timestamp":1791094470606,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,10,12]],"date-time":"2010-10-12T00:00:00Z","timestamp":1286841600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic diseases pose a severe burden to modern National Health Systems. Individuals nowadays have a far more extended lifespan than in the past, but healthy living was only scantily extended. As much as longer life is desirable, it is saddened by chronic diseases and organ malfunctions. One contributor to these problems was recognized to be represented by microparticles (MPs). Our purpose is to better understand MPs, to contrast their ominous threat and possible clinical importance. For this intent we correlated MPs with thrombotic pathologies, hemophilia, malaria, diabetes, cardiovascular diseases, endothelial dysfunctions, pulmonary hypertension, ischemic stroke, pre\u2010eclampsia, rheumatologic diseases\u2014rheumatoid arthritis, polymyositis\u2014dermatomyositis, angiogenesis and tumor progression\u2014cancer; we listed the possibilities of using them to improve transfusion methods, as a marker for acute allograft rejection, in stem cell transplantation, as neuronal biomarkers, to understand gender\u2010specific susceptibility for diseases and to improve vaccination methods and we presented some methods for the detection of MPs. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.1695","type":"journal-article","created":{"date-parts":[[2010,10,12]],"date-time":"2010-10-12T01:32:33Z","timestamp":1286847153000},"page":"539-548","source":"Crossref","is-referenced-by-count":31,"title":["Microparticles in physiological and in pathological conditions"],"prefix":"10.1002","volume":"28","author":[{"given":"Maria Augusta","family":"Roos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Gennero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetyana","family":"Denysenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Reguzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cavallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Piero","family":"Pescarmona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ponzetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2007.00532.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2006.09.001"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916930601061538"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/187153006778249976"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2007.03.008"},{"issue":"28","key":"e_1_2_6_7_2","first-page":"1376","article-title":"Cellular microparticles and blood\u2010vessel damage. I. Structure, detection and origin","volume":"148","author":"Diamant M","year":"2004","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2007.01984.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2005.08.001"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1000369"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/157489007779606121"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2004.01355.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00309.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(09)70006-4"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06514.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4509(07)90020-6"},{"issue":"1","key":"e_1_2_6_17_2","first-page":"103","article-title":"Atherothrombosis: role of tissue factor; link between diabetes, obesity and inflammation","volume":"45","author":"Meerarani P","year":"2007","journal-title":"Indian J Exp Biol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.moh.0000131441.10020.87"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000246775.14471.26"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-007-0832-0"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000744"},{"issue":"5","key":"e_1_2_6_22_2","first-page":"1934","article-title":"Platelet CD36 mediates interactions with endothelial cell\u2010derived microparticles and contributes to thrombosis in mice","volume":"118","author":"Ghosh A","year":"2008","journal-title":"J Clin Invest"},{"key":"e_1_2_6_23_2","first-page":"265","article-title":"Platelet\u2010mediated regulation of immunity","volume":"60","author":"Wazna E","year":"2006","journal-title":"Postepy Hig Med Dosw (Online)"},{"issue":"11","key":"e_1_2_6_24_2","first-page":"1096","article-title":"Platelet activation marker","volume":"51","author":"Nomura S","year":"2003","journal-title":"Rinsho Byori"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22980"},{"issue":"10","key":"e_1_2_6_26_2","first-page":"1006","article-title":"Procoagulant membranous microparticles and atherothrombotic complications in diabetics","volume":"97","author":"Morel O","year":"2004","journal-title":"Arch Mal Coeur Vaiss"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.2174\/157339909789804404"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32833640fd"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.07.012"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.12.021"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnh.0000247497.62505.72"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.2741\/1270"},{"issue":"5","key":"e_1_2_6_33_2","first-page":"1096","article-title":"Inhibition of microparticle release triggers endothelial cell apoptosis and detachment","volume":"98","author":"Abid Hussein MN","year":"2007","journal-title":"Thromb Haemost"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200706-840OC"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200710-1458OC"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-933310"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-08-0599"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2007.066167"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050224"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916930701358834"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2009.00701.x"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.11.011"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.11.7545"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1181928"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2009.12.018"},{"issue":"43","key":"e_1_2_6_46_2","first-page":"237","article-title":"Role of platelet\u2010derived microparticles in angiogenesis and tumor progression","volume":"8","author":"Varon D","year":"2009","journal-title":"Discov Med"},{"issue":"5","key":"e_1_2_6_47_2","first-page":"1070","article-title":"Effects of platelet\u2010derived membrane microparticles on angiogenesis in chick chorioallantoic membranes","volume":"15","author":"Chen BA","year":"2007","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2007.01.001"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2005.12.018"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-991540"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.6324"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.12.023"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2007.05.004"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.09.031"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2007.05.012"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06163.x"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537100701525843"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.12.006"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02922.x"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2005.09.009"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0844(199912)17:4<279::AID-CBF833>3.0.CO;2-J"},{"issue":"3","key":"e_1_2_6_62_2","first-page":"250","article-title":"Advancement of platelet activation measurement: focusing on platelet\u2010derived microparticle measurement","volume":"54","author":"Hayasaka K","year":"2006","journal-title":"Rinsho Byori"},{"issue":"3","key":"e_1_2_6_63_2","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/cyto.a.20833","article-title":"Use of SYTO 13, a fluorescent dye binding nucleic acids, for the detection of microparticles in in vitro systems","volume":"77","author":"Ullal AJ","year":"2010","journal-title":"Cytometry A"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbf.1695","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.1695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T22:41:57Z","timestamp":1760049717000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.1695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":62,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1002\/cbf.1695"],"URL":"https:\/\/doi.org\/10.1002\/cbf.1695","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"value":"0263-6484","type":"print"},{"value":"1099-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}