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In humans, 8\u2010oxoG is mainly repaired by 8\u2010oxoguanine DNA <jats:italic>N<\/jats:italic>\u2010glycosylase\u20101 (hOGG1), which is an essential component of the base excision repair (BER) pathway. The functional studies showed that hOGG1 Ser326Cys polymorphism is associated with the reduced DNA repair activity and increased risk for some oxidative stress\u2010related diseases. In this study, we firstly investigated hOGG1 Ser326Cys polymorphism in GD. According to our results, Cys\/Cys genotype frequency in the GD patients (23.4%) was significantly higher than the controls (9.2%). Cys\/Cys genotype had an 3.5\u2010fold [95% CI (confidence interval): 2.10\u20136.01, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001] the Cys allele had 1.83\u2010fold (95% CI: 1.43\u20132.34, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) increase in the risk for developing GD. Our results suggest that Ser326Cys polymorphism of the hOGG1 gene is associated with GD risk. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.1742","type":"journal-article","created":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T10:34:56Z","timestamp":1298716496000},"page":"244-248","source":"Crossref","is-referenced-by-count":13,"title":["The 8\u2010oxoguanine DNA <i>N<\/i>\u2010glycosylase 1 (hOGG1) Ser326Cys variant affects the susceptibility to Graves' 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