{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:14:17Z","timestamp":1789910057635,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,8,24]],"date-time":"2011-08-24T00:00:00Z","timestamp":1314144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>Pulmonary arterial hypertension (PAH) is a disease that increases the pulmonary vascular resistance, causing hypertrophy and subsequent right heart failure. Oxidative stress is involved in the pathogenesis of PAH, and estrogen is considered an antioxidant. Thus, the aim of this study was to test the hypothesis that estrogen could attenuate PAH by modulating oxidative stress. Female Wistar rats were ovariectomized or suffered the surgery simulation (sham). After 7\u2009days, subcutaneous pellets with 17<jats:italic>\u03b2<\/jats:italic>\u2010estradiol or sunflower oil were implanted. At this time, PAH was induced by means of a single dose of monocrotaline (MCT) (60\u2009mg\u00b7kg<jats:sup>\u20101<\/jats:sup> i.p.). The experimental groups were as follows: (1) sham, (2) sham\u2009+\u2009MCT, (3) ovariectomy (O), (4) ovariectomy\u2009+\u2009MCT (OM), (5) ovariectomy\u2009+\u2009estrogen replacement\u2009+\u2009MCT (ORM). Hemodynamic measurements were performed 21\u2009days after MCT or saline. Nonovariectomized animals were assessed in the stage of diestrus. Afterwards, the rats were killed to collect the heart, the lung and the liver to evaluate morphometry. Samples of the right ventricle were used to analyse the reduced glutathione : oxidized glutathione ratio. Lung congestion in the OM group, which was decreased in the ORM group, was observed. Right ventricle end\u2010diastolic pressure was increased in the OM and the ORM groups. The glutathione ratio decreased in the groups O, OM and ORM. The data suggest that estrogen can exert great influence on the cellular redox balance. The maintenance of physiological estrogen levels may help to avoid the appearance of pulmonary oedema, characteristic of this model of PAH, and right ventricular failure. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.1784","type":"journal-article","created":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T21:23:14Z","timestamp":1314825794000},"page":"543-548","source":"Crossref","is-referenced-by-count":11,"title":["Influence of estrogen on pulmonary arterial hypertension: role of oxidative stress"],"prefix":"10.1002","volume":"29","author":[{"given":"R.","family":"Siqueira","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Fisiologia Cardiovascular Departamento de Fisiologia Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Campos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiologia Cardiovascular Departamento de Fisiologia Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Colombo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiologia Cardiovascular Departamento de Fisiologia Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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