{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T12:31:15Z","timestamp":1763987475712,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Indoleamine 2,3\u2010dioxygenase (IDO) converts tryptophan to <jats:sc>l<\/jats:sc>\u2010kynurenine, and it is noted as a relevant molecule in promoting tolerance and suppressing adaptive immunity. In this study, to investigate the effects of IDO in carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2013induced hepatitis model, the levels of IDO enzymic activities in the mock group, the control group and the 1\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010tryptophan (1\u2010MT)\u2013treated group were confirmed by determination of <jats:sc>l<\/jats:sc>\u2010kynurenine concentrations. Serum alanine aminotransferase levels in 1\u2010MT\u2010treated rats after CCl<jats:sub>4<\/jats:sub> injection significantly increased compared with those in mock and control groups. In CCl<jats:sub>4<\/jats:sub>\u2010induced hepatitis models, tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) is critical in the development of liver injury. The mRNA expression and secretion levels of TNF\u2010\u03b1 in the liver from 1\u2010MT\u2010treated rats were more enhanced compared with those in the mock and the control groups. Moreover, the levels of cytokine and chemokine from mock, control group and 1\u2010MT\u2010treated rats after treated with CCl<jats:sub>4<\/jats:sub> were analyzed by ELISA, and the level of interleukin\u20106 was found to increase in 1\u2010MT\u2010treated rats. It was concluded that the deficiency of IDO exacerbated liver injury in CCl<jats:sub>4<\/jats:sub>\u2010induced hepatitis and its effect may be connected with TNF\u2010\u03b1 and interleukin\u20106. 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