{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:07:01Z","timestamp":1791850021203,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,22]],"date-time":"2012-04-22T00:00:00Z","timestamp":1335052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>We investigated whether treatment with imidacloprid would induce morphological changes, DNA fragmentation, antioxidant imbalance and apoptosis in the reproductive system of developing male rats. Twenty\u2010four male rats were included in this 90\u2010day study, starting at 7\u2009days of age. The rats were divided into four groups. The first group was used as control. The second, third and fourth groups received oral 0.5\u2010, 2\u2010 and 8\u2010mg\/kg imidacloprid, respectively. Serum, sperm and testis samples were collected from all groups at the end of the experimental period. The weights of the epididymis, vesicula seminalis, epididymal sperm concentration, body weight gain, testosterone and reduced glutathione values were lower in the imidacloprid\u2010treated groups than that in the controls. All treated groups had increased lipid peroxidation, fatty acid concentrations and higher rates of abnormal sperm. Apoptosis and fragmentation of seminal DNA were higher in rats treated at the two higher doses of imidacloprid. These results show that this compound has a negative effect on sperm and testis of rats. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.2826","type":"journal-article","created":{"date-parts":[[2012,4,22]],"date-time":"2012-04-22T20:58:29Z","timestamp":1335128309000},"page":"492-499","source":"Crossref","is-referenced-by-count":159,"title":["Insecticide imidacloprid induces morphological and DNA damage through oxidative toxicity on the reproductive organs of developing male rats"],"prefix":"10.1002","volume":"30","author":[{"given":"Ramazan","family":"Bal","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Physiology Firat University  Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Naziro\u011flu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Biophysics Suleyman Demirel University  Isparta 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