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The aim of this study was to evaluate the hepatoprotective effect of <jats:italic>bis<\/jats:italic>(4\u2010methylbenzoyl) diselenide (BMD) against carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2013induced oxidative damage in mice. The animals received BMD (25 mg\/kg p.o., for 3 days), and after 1 day, CCl<jats:sub>4<\/jats:sub> (1 mg\/kg body weight) was administered by intraperitoneal route. One day after the CCl<jats:sub>4<\/jats:sub> exposure, the animals were euthanized for biochemical and histological analysis. Treatment with BMD (25 mg\/kg p.o.) protected against aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma\u2010glutamyl transferase and lactate dehydrogenase activity increases induced by CCl<jats:sub>4<\/jats:sub> plasma exposure. Treatment with BMD (25 mg\/kg) protected against increases in thiobarbituric reactive species and decreasing non\u2010protein thiols and ascorbic acid levels in liver of mice. Catalase and superoxide dismutase activity inhibition in the liver caused by CCl<jats:sub>4<\/jats:sub> were protected by treatment with BMD (25 mg\/kg). Glutathione S\u2010transferase activity was inhibited by CCl<jats:sub>4<\/jats:sub> and remained unaltered even after treatment with BMD. Sections of liver from CCl<jats:sub>4<\/jats:sub>\u2010exposed mice presented an intense infiltration of inflammatory cells and loss of the cellular architecture. BMD (25 mg\/kg) attenuated CCl<jats:sub>4<\/jats:sub>\u2010induced hepatic histological alterations. The results demonstrated the hepatoprotective effects of BMD in the mouse liver, possibly by modulating the antioxidant status. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.2869","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T09:30:18Z","timestamp":1347010218000},"page":"152-158","source":"Crossref","is-referenced-by-count":10,"title":["Hepatoprotective effect of <i>bis<\/i>(4\u2010methylbenzoyl) diselenide against CCl<sub>4<\/sub>\u2010induced oxidative damage in mice"],"prefix":"10.1002","volume":"31","author":[{"given":"Carlos Borges","family":"Filho","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Avalia\u00e7\u00f5es Farmacol\u00f3gicas e Toxicol\u00f3gicas Aplicadas \u00e0s Mol\u00e9culas Bioativas, LaftamBio Pampa Universidade Federal do Pampa  CEP 97650\u2010000 Itaqui RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucian","family":"Del Fabbro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Avalia\u00e7\u00f5es Farmacol\u00f3gicas e Toxicol\u00f3gicas Aplicadas 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