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These cells were found to contain different forms of cytochrome P<jats:sub>450<\/jats:sub>, as shown by the response to inducers, namely phenobarbital (PB), 3\u2010methylcholanthrene (MC) and metyrapone (MP). MH<jats:sub>1<\/jats:sub>C<jats:sub>1<\/jats:sub> cell monolayers exposed to PB or MC showed an increase in the concentration of two spectrally distinct forms of cytochrome P<jats:sub>450<\/jats:sub>. The PB and MC treatments elicited enzyme activities towards the substrates aminopyrine and benzo(<jats:italic>a<\/jats:italic>)pyrene, respectively. The cell treatment with metyrapone led to a simultaneous stimulation of aminopyrine demethylase and benzo(a)pyrene hydroxylase activities, so underlining the peculiar features of this inducer.<\/jats:p>","DOI":"10.1002\/cbf.290020415","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T18:48:48Z","timestamp":1117219728000},"page":"263-268","source":"Crossref","is-referenced-by-count":10,"title":["Induction of cytochrome(s) P<sub>450<\/sub>\u2010dependent drug metabolism in cultured MH<sub>1<\/sub>C<sub>1<\/sub> hepatoma cells"],"prefix":"10.1002","volume":"2","author":[{"given":"Margherita","family":"Ferro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Bassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto M.","family":"Marinari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Nanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Chiarpotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Poli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario U.","family":"Dianzani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00343281"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6771871"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(80)90178-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-7992(81)90069-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-7992(81)90054-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(82)90031-0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/3.10.1213"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(83)90138-0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(83)90097-0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"11324","DOI":"10.1016\/S0021-9258(19)70295-6","article-title":"Hydroxylation, sulfation and conjugation of bile acids in rat hepatoma and hepatocyte cultures under the influence of glucocorticoids","volume":"255","author":"Lambiotte M.","year":"1980","journal-title":"J. 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