{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:16:29Z","timestamp":1761707789249,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,2,17]],"date-time":"2004-02-17T00:00:00Z","timestamp":1076976000000},"content-version":"vor","delay-in-days":4522,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[1991,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The possible effect of melatinin, 5\u2010methoxytryptamine, 5\u2010methoxytryptophol, 6\u2010chloromelatonin and 2\u2010iodomelatonin on testosterone production by Leydig cells <jats:italic>in vitro<\/jats:italic> was investigated. The ability of individual indoles to inhibit testosterone production was found to depend on the concentration used. The relative inhibitory potency of the compounds tested was: 6\u2010chloromelationin &gt; 2\u2010iodomelatonin &gt; melatonin &gt; 5\u2010methoxytryptamine &gt; 5\u2010methoxytryptophol. The results revealed that natural indoles which are synthesized in the pineal gland and their halogenized derivatives are capable of influencing directly testosterone production by Leydig cells. Also, these results demonstrated that melatonin exerts its remarkable antigonadotrophic effects, at least in part, through the direct decrease of testosterone production. Moreover, 6\u2010chloromelationin and 2\u2010iodomelatonin, which are reported to inhibit melatonin binding to target tissues, possess properties of biological melatonin analogues under the conditions of the model system used.<\/jats:p>","DOI":"10.1002\/cbf.290090410","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T10:45:57Z","timestamp":1117277157000},"page":"281-286","source":"Crossref","is-referenced-by-count":24,"title":["Inhibitory action of melatonin and structurally related compounds on testosterone production by mouse leydig cells <i>in vitro<\/i>"],"prefix":"10.1002","volume":"9","author":[{"given":"S.","family":"Persengiev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kehajova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-1-2-109"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-1451-7_17"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(86)90047-0"},{"key":"e_1_2_1_5_2","first-page":"195","volume-title":"The Pineal Gland and Cancer","author":"Blask D. 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