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Likewise, in intact islets of thyroidectomized rats, the generation of<jats:sup>3<\/jats:sup>HOH from [2\u2010<jats:sup>3<\/jats:sup>H]glycerol was not decreased, and the ratio between oxidative and total glycolysis not significantly lower than in islets from sham\u2010operated rats, at least in the presence of a high concentration of D\u2010glucose. Nevertheless impaired oxidation of both D\u2010[3,4\u2010<jats:sup>14<\/jats:sup>C]glucose and D\u2010[6\u2010<jats:sup>14<\/jats:sup>C]glucose was observed in islets of thyroidectomized rats, the relative magnitude of such a decrease being more pronounced at a low than at a high D\u2010glucose concentration. Such metabolic anomalies coincided with a lower level of plasma insulin and a decreased output of insulin by islets incubated at low (2\u00b78 m<jats:sc>M<\/jats:sc>), but not higher, concentrations of D\u2010glucose. It is concluded that hypothyroidism does not mimic the deficiency in islet FAD\u2010linked glycerophosphate dehydrogenase activity found in rats with inherited or acquired non\u2010insulin\u2010dependent diabetes.<\/jats:p>","DOI":"10.1002\/cbf.290110211","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T10:52:55Z","timestamp":1117277575000},"page":"145-151","source":"Crossref","is-referenced-by-count":1,"title":["Enzymatic, metabolic and secretory perturbations in pancreatic islets of thyroidectomized rats"],"prefix":"10.1002","volume":"11","author":[{"given":"Abdullah","family":"Sener","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine","family":"Malaisse\u2010Lagae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Gervy\u2010Decoster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willy J.","family":"Malaisse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.40.2.227"},{"issue":"1","key":"e_1_2_1_3_2","first-page":"A78","article-title":"Preferential alteration of oxidative relative to total glycolysis in islets of rats with inherited or acquired non\u2010insulin\u2010dependent diabetes","volume":"35","author":"Sener A.","year":"1992","journal-title":"Diabetologia"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0021-9258(18)97593-9","article-title":"Influence of thyroid hormones on L\u2010\u03b1\u2010glycerophosphate dehydrogenases and other dehydrogenases in various organs of the rats","volume":"240","author":"Lee Y.\u2010P.","year":"1965","journal-title":"J. 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