{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:06:18Z","timestamp":1760141178845,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,2,17]],"date-time":"2004-02-17T00:00:00Z","timestamp":1076976000000},"content-version":"vor","delay-in-days":3821,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of propranolol on the process of thyroid hormone formation was studied in a physiological culture system. Porcine thyroid follicles were preincubated with propranolol for 24 h. Iodide transport, iodine organification, and <jats:italic>de novo<\/jats:italic> thyroid hormone formation were measured by incubating these follicles with the mixture of carrier\u2010free 0\u00b71 \u03bcCi Na <jats:sup>125<\/jats:sup>I and 50 n<jats:sc>M<\/jats:sc> NaI for 2 to 6 h at 37\u00b0C. A concentration of propranolol greater than 100 \u03bc<jats:sc>M<\/jats:sc> inhibited iodide transport in a dose\u2010dependent manner; this inhibition was non\u2010competitive with iodide and independent of thyrotropin (TSH). Reduced iodine organification and thyroid hormone formation was seen with 150 \u03bc<jats:sc>M<\/jats:sc> propranolol or greater. The inhibitory action of propranolol was not caused by beta\u2010blocking activity, since <jats:sc>D<\/jats:sc>\u2010propranolol (devoid of beta\u2010blocking activity) inhibited iodide transport, and other beta\u2010blockers (metoprolol, atenolol, and labetalol) did not inhibit iodide transport. The inhibition of iodide transport was most likely caused by membrane stabilizing activity since quinidine, which possess the same membrane stabilizing activity as propranolol, also inhibited iodide transport. TSH\u2010mediated cAMP generation and Na <jats:sup>+<\/jats:sup>K<jats:sup>+<\/jats:sup> ATPase activity, membrane functions for iodide transport, were unaffected by propranolol.<\/jats:p><jats:p>Our study has shown, for the first time, that propranolol has a direct antithyroid action, namely inhibition of iodide transport in the intact thyroid follicle.<\/jats:p>","DOI":"10.1002\/cbf.290110303","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T10:53:15Z","timestamp":1117277595000},"page":"159-165","source":"Crossref","is-referenced-by-count":5,"title":["Propranolol has direct antithyroid activity: Inhibition of iodide transport in cultured thyroid follicles"],"prefix":"10.1002","volume":"11","author":[{"given":"Saburo","family":"Murakami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiyo","family":"Nasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harushisa","family":"Fukayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalita","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Sugawara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90681-Z"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-44-5-1002"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-45-2-293"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-106-5-1437"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1990.tb00877.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1991.1.273"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90778-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1985.28"},{"key":"e_1_2_1_10_2","first-page":"171","article-title":"Propranolol\u2010induced hyperthyroxinemia in a patient with an autonomous thyroid nodule","volume":"25","author":"Charkes N. D.","year":"1987","journal-title":"J. Family Practice"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-84-5-1009"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1152\/ajplegacy.1970.218.5.1445","article-title":"Effects of prostagladins on basal and stimulated thyroid function","volume":"218","author":"Burke G.","year":"1970","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-96-6-1513"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-100-4-974"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-126-3-1692"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-129-2-807"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1991.1.267"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-123-4-1977"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-114-4-1090"},{"key":"e_1_2_1_20_2","first-page":"610","article-title":"Hydrogen peroxide inhibits iodide influx and enhances iodide efflux in cultured FRTL\u20105 rat thyroid cells","volume":"122","author":"Sugawara M.","year":"1990","journal-title":"Acta Endocrinol, (Copenh)"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-79-4-801"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5747.490"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1980.tb04793.x"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1982.tb04937.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6669.294"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000433-198803000-00012"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbf.290110303","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.290110303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:10:12Z","timestamp":1760055012000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.290110303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["10.1002\/cbf.290110303"],"URL":"https:\/\/doi.org\/10.1002\/cbf.290110303","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"type":"print","value":"0263-6484"},{"type":"electronic","value":"1099-0844"}],"subject":[],"published":{"date-parts":[[1993,9]]}}}