{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:05:20Z","timestamp":1760141120248,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,2,17]],"date-time":"2004-02-17T00:00:00Z","timestamp":1076976000000},"content-version":"vor","delay-in-days":3821,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have tested the effect of alkaloids (cocaine, morphine) and enkephalins on neutral endopeptidase of peripheral blood mononuclear cells activated by lectins. When treated with concanavalin A and cocaine, peripheral blood mononuclear cells showed an enhanced activity (+110 per cent) of the membrane neutral endopeptidase, which was not related to the expression of the common acute lymphoblastic leukemia antigen at the cell surface, although both molecules have the identical amino acid sequence. Phytohemagglutinin\u2010P, morphine and synthetic enkephalins did not induce the activity of neutral endopeptidase nor the expression of common acute lymphoblastic leukemia antigen. Our findings suggested that the drugs of abuse, cocaine and morphine, affected specific membrane constituents without altering proliferation, subcellular localization of membrane enzymes or the surface immune phenotype of peripheral blood mononuclear cells.<\/jats:p>","DOI":"10.1002\/cbf.290110309","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T10:53:15Z","timestamp":1117277595000},"page":"211-219","source":"Crossref","is-referenced-by-count":3,"title":["Effect of cocaine and morphine on neutral endopeptidase activity of human peripheral blood mononuclear cells cultured with lectins"],"prefix":"10.1002","volume":"11","author":[{"given":"Lorenzo M.","family":"Leoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele A.","family":"Losa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(80)90044-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111607"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.157.3.1064"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb00189.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.4.1249"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.4049\/jimmunol.130.5.2456","article-title":"Expression of common acute lymphoblastic leukemia antigen (CALLA) on human malignant melanoma cell lines","volume":"130","author":"Carrel S.","year":"1983","journal-title":"J. Immunol."},{"key":"e_1_2_1_8_2","first-page":"343","article-title":"Identification of myoepithelial cells in human and rat breasts by anti\u2010common acute lymphoblastic leukemia antigen antibody A\u201012","volume":"77","author":"Gusterson B. A.","year":"1986","journal-title":"J. Natl. Cancer Inst."},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.4.1247"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/276523a0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91663-5"},{"key":"e_1_2_1_12_2","first-page":"437","article-title":"Neutral metalloendopeptidase in human male genital tract. Comparison to angiotensin I converting enzyme","volume":"52","author":"Erd\u00f6s E. G.","year":"1985","journal-title":"Lab. Invest."},{"key":"e_1_2_1_13_2","first-page":"564","article-title":"Neutral metalloendopeptidase in human lung tissue and cultured cells","volume":"132","author":"Johnson A. R.","year":"1985","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"9456","DOI":"10.1016\/S0021-9258(19)76562-4","article-title":"Function of neutral endopeptidase on the cell membrane of human neutrophils","volume":"263","author":"Painter R. G.","year":"1988","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(89)80148-2"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00282a035"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)80375-2"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(84)90020-2"},{"key":"e_1_2_1_19_2","first-page":"192","article-title":"Immune function in heroin addicts and former heroin addicts in treatment: Pre\u2010 and post\u2010AIDS epidemic","volume":"96","author":"Kreek M. J.","year":"1990","journal-title":"Nida Res. Monogr."},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5925-8_19"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(86)90123-6"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(89)80026-8"},{"key":"e_1_2_1_23_2","first-page":"451","article-title":"Immunological abnormalities in intravenous drug abusers and relationship to the prolonged generalized lymphadenopathy syndrome in Italy","volume":"64","author":"De Paoli P.","year":"1986","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(90)90087-7"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5925-8_18"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(90)90205-6"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1096\/fasebj.5.8.2022315","article-title":"Inhibition of calcium mobilization is an early event in opiate\u2010induced immunosuppression","volume":"5","author":"Sei Y.","year":"1991","journal-title":"FASEB J."},{"key":"e_1_2_1_28_2","first-page":"191","article-title":"Correlations between enzymatic and immunologic properties of human peripheral blood mononuclear cells. I. Ectoenzymes of normal and immunodeficient peripheral blood mononuclear cells","volume":"107","author":"Losa G. A.","year":"1982","journal-title":"Am. J. Path."},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000469046","article-title":"Subcellular localization and kinetic properties of phosphatidylinositol 4,5\u2010biphosphate phospholipase C and inositol phosphate enzymes from human peripheral blood mononuclear cells","volume":"41","author":"Graber R.","year":"1989","journal-title":"Enzyme"},{"key":"e_1_2_1_30_2","first-page":"265","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry O.","year":"1951","journal-title":"Biochem. J."},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(84)90425-1"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac60119a033"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-21613-2"},{"key":"e_1_2_1_35_2","first-page":"573","article-title":"Characterization of membrane vesicles circulating in the serum of patients with common acute lymphoblastic leukemia","volume":"55","author":"Losa G. A.","year":"1986","journal-title":"Lab. Invest."},{"key":"e_1_2_1_36_2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1182\/blood.V76.4.775.775","article-title":"Comparative levels of CALLA\/neutral endopeptidase on normal granulocytes, leukemic cells, and transfected COS\u20101 cells","volume":"76","author":"Tran\u2010Paterson R.","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.49.2.116"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0192-0561(92)90104-S"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(83)90083-2"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb35834.x"},{"key":"e_1_2_1_41_2","first-page":"A74","article-title":"Enzyme characterization of PBMN cells in drug abusers with and without seroconversion","volume":"47","author":"Leoni L. M.","year":"1991","journal-title":"Experientia"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90247-G"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(87)90082-4"},{"key":"e_1_2_1_44_2","first-page":"1","article-title":"Subcellular localization of inositide enzymes in established T\u2010cell lines and activated lymphocytes","volume":"5","author":"Graber R.","year":"1993","journal-title":"Anal. Cell Pathol."},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.06.040188.001251"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.1985.Supplement_3.19"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbf.290110309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.290110309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:10:26Z","timestamp":1760055026000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.290110309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["10.1002\/cbf.290110309"],"URL":"https:\/\/doi.org\/10.1002\/cbf.290110309","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"type":"print","value":"0263-6484"},{"type":"electronic","value":"1099-0844"}],"subject":[],"published":{"date-parts":[[1993,9]]}}}