{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:10:46Z","timestamp":1783476646254,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,5]],"date-time":"2013-05-05T00:00:00Z","timestamp":1367712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>The protective roles of lipoic acid (LA)\/vitamin C (VC) and mesna on preventing cyclophosphamide (CYP)\u2010induced haemorrhagic cystitis (HC) were investigated. Swiss mice were divided into five groups randomly. HC was induced by a single dose of CYP injection (150\u2010mg\u2009kg<jats:sup>\u22121<\/jats:sup> bodyweight). Group I was injected with saline (four times in total) throughout as control group. Group II received CYP and three equal doses of saline. Group III received CYP and three doses of mesna, whereas Group IV (or Group V) received CYP, mesna\u2009+\u2009two doses of VC (or LA). All injections were performed intraperitoneally. After 24\u2009h of cystitis induction, the bladders were collected for all the experiments. Histological characterization showed that CYP injection resulted in severe HC. Reactive oxygen species (ROS) and thiobarbituric acid reactive substances' levels were increased in CYP group. The activities of antioxidant enzymes, e.g. superoxide dismutase, catalase, glutathione S\u2010transferase and glutathione peroxidase, were inhibited significantly in CYP groups, respectively. In addition, activation of c\u2010jun N\u2010terminal kinases (JNK) and p38 mitogen\u2010activated protein kinase (MAPK) may be involved in the mechanism of CYP\u2010induced HC but not extracellular signal regulated kinases (ERK). Significant suppression of p38 phosphorylation on Group V suggests that LA and mesna may have synergistic beneficial effect. In Groups III\u2013V, all the parameters of HC and oxidative stress were inhibited significantly. Taking together, we found that these results illustrated that ROS play an important role on CYP\u2010induced HC and the administration of LA\/VC with mesna may have therapeutic potential against CYP\u2010induced bladder HC. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.2978","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T00:19:12Z","timestamp":1367799552000},"page":"125-132","source":"Crossref","is-referenced-by-count":32,"title":["Protective effects of lipoic acid and mesna on cyclophosphamide\u2010induced haemorrhagic cystitis in mice"],"prefix":"10.1002","volume":"32","author":[{"given":"Jianbo","family":"Song","sequence":"first","affiliation":[{"name":"Key Laboratory of Luminescence and Real\u2010Time Analysis, Ministry of Education, College of Pharmaceutical Sciences Southwest University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichao","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Luminescence and Real\u2010Time Analysis, Ministry of Education, College of Pharmaceutical Sciences Southwest University  Chongqing 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