{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T08:01:51Z","timestamp":1773734511965,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:00:00Z","timestamp":1368576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Gout is an inflammatory joint disorder characterized by hyperuricaemia and precipitation of monosodium urate crystals in the joints. In the present study, we aimed to investigate the anti\u2010inflammatory effect of trikatu, a herbal compound in monosodium urate crystal\u2010induced inflammation in rats, an experimental model for acute gouty arthritis. Paw volume and levels\/activities of lysosomal enzymes, lipid peroxidation, anti\u2010oxidant status and histopathological examination of ankle joints were determined in control and monosodium urate crystal\u2010induced rats. In addition, analgesic (acetic acid\u2010induced writhing response), anti\u2010pyretic (yeast\u2010induced pyrexia) and gastric ulceration effects were tested. The levels of lysosomal enzymes, lipid peroxidation and paw volume were significantly increased, and anti\u2010oxidant status was found to be reduced in monosodium urate crystal\u2010induced rats, whereas the biochemical changes were reverted to near normal levels upon trikatu (1000\u2009mg\/kg b.wt) administration. The trikatu has also been found to exhibit significant analgesic and anti\u2010pyretic effects with the absence of gastric damage. In conclusion, the present results clearly indicated that trikatu exert a potent anti\u2010inflammatory effect against monosodium urate crystal\u2010induced inflammation in rats in association with analgesic and anti\u2010pyretic effects in the absence of gastrointestinal damage. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.2979","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T07:10:52Z","timestamp":1368601852000},"page":"106-114","source":"Crossref","is-referenced-by-count":17,"title":["Trikatu, a herbal compound that suppresses monosodium urate crystal\u2010induced inflammation in rats, an experimental model for acute gouty arthritis"],"prefix":"10.1002","volume":"32","author":[{"given":"Vachana","family":"Murunikkara","sequence":"first","affiliation":[{"name":"Immunopathology Lab, School of Bio Sciences and Technology VIT University  Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MahaboobKhan","family":"Rasool","sequence":"additional","affiliation":[{"name":"Immunopathology Lab, School of Bio Sciences and Technology VIT University  Vellore 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