{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:44:42Z","timestamp":1760204682562,"version":"build-2065373602"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T00:00:00Z","timestamp":1394582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>This study evaluated the effects of HgCl<jats:sub>2<\/jats:sub> on renal parameters in nonlactating and lactating rats and their pups, as well as the preventive role of ZnCl<jats:sub>2<\/jats:sub>. Rats received 27\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> ZnCl<jats:sub>2<\/jats:sub> for five consecutive days and 5\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> HgCl<jats:sub>2<\/jats:sub> for five subsequent days (s.c.). A decrease in <jats:italic>\u03b4<\/jats:italic>\u2010aminolevulinic acid dehydratase (<jats:italic>\u03b4<\/jats:italic>\u2010ALA\u2010D) activity in the blood and an increase in urine protein content in renal weight as well as in blood and urine Hg levels were observed in lactating and nonlactating rats from Sal\u2015Hg and Zn\u2015Hg groups. ZnCl<jats:sub>2<\/jats:sub> prevented partially the <jats:italic>\u03b4<\/jats:italic>\u2010ALA\u2010D inhibition and the proteinuria in nonlactating rats. Renal Hg levels were increased in all HgCl<jats:sub>2<\/jats:sub> groups, and the ZnCl<jats:sub>2<\/jats:sub> exposure potentiated this effect in lactating rats. Nonlactating rats exposed to HgCl<jats:sub>2<\/jats:sub> exhibited an increase in plasma urea and creatinine levels, <jats:italic>\u03b4<\/jats:italic>\u2010ALA\u2010D activity inhibition and histopathological alterations (necrosis, atrophic tubules and collagen deposition) in the kidneys. ZnCl<jats:sub>2<\/jats:sub> exposure prevented the biochemical alterations. Hg\u2010exposed pups showed lower body and renal weight and an increase in the renal Hg levels. In conclusion, mercury\u2010induced nephrotoxicity differs considerably between lactating and nonlactating rats. Moreover, prior exposure with ZnCl<jats:sub>2<\/jats:sub> may provide protection to individuals who get exposed to mercury occupationally or accidentally. 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