{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:20:25Z","timestamp":1790630425975,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T00:00:00Z","timestamp":1409702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research Projects Coordination Unit of Istanbul University","award":["7823"],"award-info":[{"award-number":["7823"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>The objectives of study were (a) to determine alteration of feeding, glucose level and oxidative stress and (b) to investigate expression and localization of cannabinoid receptors in type\u20102 diabetic rat pancreas treated with \u0394<jats:sup>9<\/jats:sup>\u2010tetrahydrocannabinol (\u0394<jats:sup>9<\/jats:sup>\u2010THC). Rats were randomly divided into four groups: control, \u0394<jats:sup>9<\/jats:sup>\u2010THC, diabetes and diabetes\u2009+\u2009\u0394<jats:sup>9<\/jats:sup>\u2010THC groups. Diabetic rats were treated with a single dose of nicotinamide (85\u2009mg\/kg) 15\u2009min before injection of streptozotocin (65\u2009mg\/kg). \u0394<jats:sup>9<\/jats:sup>\u2010THC was administered intraperitoneally at 3\u2009mg\/kg\/day for 7\u2009days. Body weights and blood glucose level of rats in all groups were measured on days\u20090, 7, 14 and 21. On day\u200915 after the \u0394<jats:sup>9<\/jats:sup>\u2010THC injections, pancreatic tissues were removed. Blood glucose levels and body weights of diabetic rats treated with \u0394<jats:sup>9<\/jats:sup>\u2010THC did not show statistically significant changes when compared with the diabetic animals on days\u20097, 14 and 21. Treatment with \u0394<jats:sup>9<\/jats:sup>\u2010THC significantly increased pancreas glutathione levels, enzyme activities of superoxide dismutase and catalase in diabetes compared with non\u2010treatment diabetes group. The cannabinoid 1 receptor was found in islets, whereas the cannabinoid 2 receptor was found in pancreatic ducts. Their localization in cells was both nuclear and cytoplasmic. We can suggest that \u0394<jats:sup>9<\/jats:sup>\u2010THC may be an important agent for the treatment of oxidative damages induced by diabetes. However, it must be supported with anti\u2010hyperglycaemic agents. Furthermore, the present study for the first time emphasizes that \u0394<jats:sup>9<\/jats:sup>\u2010THC may improve pancreatic cells via cannabinoid receptors in diabetes.<\/jats:p><jats:p>The aim of present study was to elucidate the effects of \u0394<jats:sup>9<\/jats:sup>\u2010THC, a natural cannabinoid receptor agonist, on the expression and localization of cannabinoid receptors, and oxidative stress statue in type\u20102 diabetic rat pancreas. Results demonstrate that the cannabinoid receptors are presented in both Langerhans islets and duct regions. The curative effects of \u0394<jats:sup>9<\/jats:sup>\u2010THC can be occurred via activation of cannabinoid receptors in diabetic rat pancreas. Moreover, it may provide a protective effect against oxidative damage induced by diabetes. Thus, it is suggested that \u0394<jats:sup>9<\/jats:sup>\u2010THC can be a candidate for therapeutic alternatives of diabetes symptoms. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.3058","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T03:14:05Z","timestamp":1409714045000},"page":"612-619","source":"Crossref","is-referenced-by-count":18,"title":["Oxidative stress and cannabinoid receptor expression in type\u20102 diabetic rat pancreas following treatment with \u0394<sup>9<\/sup>\u2010THC"],"prefix":"10.1002","volume":"32","author":[{"given":"Zeynep Mine","family":"Coskun","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Arts and Sciences Istanbul Bilim University  Istanbul Turkey"},{"name":"Department of Medical Biology, Faculty of Cerrahpasa Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema","family":"Bolkent","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Cerrahpasa Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.183"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16129912"},{"key":"e_1_2_7_4_1","first-page":"1624","article-title":"Vitamin E, its beneficial role in diabetes mellitus (DM) and its complications","volume":"6","author":"Baburao Jain A","year":"2012","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-5441-0_21"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2013.03.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2012.01.020"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.07.028"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/346561a0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/365061a0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707442"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-02-00563.1991"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704327"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.54.2.161"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.10.006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e328304b62b"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32834455a8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2005.10.005"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.12.016"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2012.02325.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.128272"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-013-9445-9"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.47.2.224"},{"key":"e_1_2_7_24_1","volume-title":"Red Cell Metabolism: A Manual of Biochemical Methods","author":"Beutler E","year":"1971"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(86)90247-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.3.497"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.2.244"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2013.05.013"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-010-0041-y"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00467-1"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.178.2.107"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.01.025"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145709990605"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8490.94719"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2012.01.002"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802250"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.19"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01422.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.11.051"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2011.10.003"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2004.10.044"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2010007500015"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2013.03.001"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0890-y"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.4161\/isl.2.5.12729"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.05.077"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2007.08.009"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbf.3058","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.3058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:13:12Z","timestamp":1760055192000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.3058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,3]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1002\/cbf.3058"],"URL":"https:\/\/doi.org\/10.1002\/cbf.3058","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"value":"0263-6484","type":"print"},{"value":"1099-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,3]]}}}