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Considering that diabetic rats and mice present higher depressive\u2010like behaviour when submitted to the forced swimming test and that treatment with insulin and\/or clonazepam is able to reverse the behavioural changes of the diabetic rats, the present work investigated the antioxidant status, specifically total antioxidant reactivity and antioxidant potential of insulin and clonazepam, as well as the effect of this drugs upon protein oxidative damage and reactive species formation in cortex, hippocampus and striatum from diabetic rats submitted to forced swimming test. It was verified that longer immobility time in diabetic rats and insulin plus clonazepam treatment reversed this depressive\u2010like behaviour. Moreover, data obtained in this study allowed to demonstrate through different parameters such as protein carbonyl content, 2\u20327\u2032\u2010dichlorofluorescein oxidation, catalase, superoxide dismutase, glutathione peroxidase assay, total radical\u2010trapping antioxidant potential and total antioxidant reactivity that there is oxidative stress in cortex, hippocampus and striatum from diabetic rats under depressive\u2010like behaviour and highlight the insulin and\/or clonazepam effect in these different brain areas, restoring antioxidant status and protein damage. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.3076","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T13:33:02Z","timestamp":1417181582000},"page":"711-719","source":"Crossref","is-referenced-by-count":17,"title":["Diabetic encephalopathy\u2010related depression: experimental evidence that insulin and clonazepam restore antioxidant status in rat brain"],"prefix":"10.1002","volume":"32","author":[{"given":"Carlos Alberto Yasin","family":"Wayhs","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas UFRGS  Porto Alegre Rio Grande do Sul Brazil"},{"name":"Servi\u00e7o de Gen\u00e9tica M\u00e9dica, Hospital de Cl\u00ednicas de Porto Alegre UFRGS  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Paula","family":"Mescka","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de 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