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Treatment of rats with cranberry flavonoids (7\u2009mg\/kg) during chronic carbon tetrachloride\u2010induced intoxication led to prevention of mitochondrial damage, including fragmentation, rupture and local loss of the outer mitochondrial membrane. In radical\u2010generating systems, cranberry flavonoids effectively scavenged nitric oxide (IC<jats:sub>50<\/jats:sub>\u2009=\u20094.4\u2009\u00b1\u20090.4\u2009\u00b5g\/ml), superoxide anion radicals (IC<jats:sub>50<\/jats:sub>\u2009=\u20092.8\u2009\u00b1\u20090.3\u2009\u00b5g\/ml) and hydroxyl radicals (IC<jats:sub>50<\/jats:sub>\u2009=\u200953\u2009\u00b1\u20094\u2009\u00b5g\/ml). The IC<jats:sub>50<\/jats:sub> for reduction of 1,1\u2010diphenyl\u20102\u2010picrylhydrazyl radicals (DPPH) was 2.2\u2009\u00b1\u20090.3\u2009\u00b5g\/ml. Flavonoids prevented to some extent lipid peroxidation in liposomal membranes and glutathione oxidation in erythrocytes treated with UV irradiation or organic hydroperoxides as well as decreased the rigidity of the outer leaflet of the liposomal membranes. The hepatoprotective potential of cranberry flavonoids could be due to specific prevention of rat liver mitochondrial damage. The mitochondria\u2010addressed effects of flavonoids might be related both to radical\u2010scavenging properties and modulation of various mitochondrial events. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.3104","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T04:21:23Z","timestamp":1431318083000},"page":"202-210","source":"Crossref","is-referenced-by-count":13,"title":["Cranberry flavonoids prevent toxic rat liver mitochondrial damage <i>in vivo<\/i> and scavenge free radicals <i>in vitro<\/i>"],"prefix":"10.1002","volume":"33","author":[{"given":"Elena A.","family":"Lapshina","sequence":"first","affiliation":[{"name":"Department of Biochemistry Yanka Kupala State University of Grodno  Grodno Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Zamaraeva","sequence":"additional","affiliation":[{"name":"Department of Biophysics University of Bialystok  Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitali T.","family":"Cheshchevik","sequence":"additional","affiliation":[{"name":"Department of 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