{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:23:52Z","timestamp":1790231032022,"version":"4.1.0"},"reference-count":181,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Nowadays, obesity is considered as a serious and growing global health problem. It is documented that the overweight and obesity are major risk factors for a series of noncommunicable diseases, and in recent years, the obesity\u2010cancer link has received much attention. Numerous epidemiological studies have shown that obesity is associated with increased risk of several cancer types, including colon, breast, endometrium, liver, kidney, esophagus, gastric, pancreatic, gallbladder, and leukemia, and can also lead to poorer treatment.<\/jats:p><jats:p>We review here the epidemiological and experimental evidences for the association between obesity and cancer. Specifically, we discuss potential mechanisms focusing how dysfunctional angiogenesis, chronic inflammation, interaction of proinflammatory cytokines, endocrine hormones, and adipokines including leptin, adiponectin insulin, growth factors, estrogen, and progesterone and strikingly, cell metabolism alteration in obesity participate in tumor development and progression, resistance to chemotherapy, and targeted therapies such as antiangiogenic and immune therapies.<\/jats:p>","DOI":"10.1002\/cbf.3229","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T05:45:28Z","timestamp":1478756728000},"page":"533-545","source":"Crossref","is-referenced-by-count":102,"title":["From obesity to cancer: a review on proposed mechanisms"],"prefix":"10.1002","volume":"34","author":[{"given":"Zoya","family":"Tahergorabi","sequence":"first","affiliation":[{"name":"Department of Physiology, Cellular and Molecular Research Center Birjand University of Medical Sciences  Birjand Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Khazaei","sequence":"additional","affiliation":[{"name":"Department of Physiology Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Moodi","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center Birjand University of Medical Sciences  Birjand Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Chamani","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cellular and Molecular Research Center Birjand University of Medical Sciences  Birjand Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2011.08.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-143"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.199"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2007.00462.x"},{"issue":"1","key":"e_1_2_6_6_1","first-page":"2","article-title":"Epidemiology of obesity in developing countries: challenges and prevention. Global epidemic","volume":"2","author":"Ellulu M","year":"2014","journal-title":"Obesity"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055643"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2009.00712.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.10.008"},{"key":"e_1_2_6_10_1","volume-title":"IARC Handbook of Cancer Prevention, Volume 6: Weight Control and Physical Activity","author":"Group IW","year":"2002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-010-9536-x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2015.08.014"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21142"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06750.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2006-0001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011023431804"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0300"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20778"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:CACO.0000016573.79453.ba"},{"issue":"8","key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"830","DOI":"10.6004\/jnccn.2011.0072","article-title":"Esophageal and esophagogastric junction cancers","volume":"9","author":"Ajani JA","year":"2011","journal-title":"J Natl Compr Canc Netw"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0860"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066555"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001200"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027960"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060939"},{"issue":"4","key":"e_1_2_6_26_1","first-page":"248","article-title":"Gamma\u2010secretase inhibitor does not modulate angiogenesis in colon adenocarcinoma in obese mice","volume":"116","author":"Khazaei M","year":"2014","journal-title":"Bratisl Lek Listy"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141121240"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2678"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12416"},{"issue":"4","key":"e_1_2_6_30_1","first-page":"247","article-title":"The relationship between inflammatory markers, angiogenesis, and obesity","volume":"9","author":"Tahergorabi Z","year":"2013","journal-title":"ARYA Atheroscler"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-016-0957-1"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601911432334"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000121425.42966.F1"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12270"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141392"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.5539\/gjhs.v7n7p69"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000259564.92792.93"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-011-0183-1"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-007-0281-3"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-007-9074-0"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0911"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06737.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071812-161113"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-11-0110"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0241"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00333.2007"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00192-09"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.054"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1385\/1-59745-113-4:73"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006020185"},{"issue":"11","key":"e_1_2_6_51_1","first-page":"1124","article-title":"The involvement of VEGF in endothelial permeability: a target for anti\u2010inflammatory therapy","volume":"6","author":"Lee YC","year":"2005","journal-title":"Curr Opin Investig Drugs"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi100330w"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.06.013"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.3653"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3455"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.8021"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.27810"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2012-1283"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0157"},{"issue":"2","key":"e_1_2_6_60_1","first-page":"82","article-title":"Role of anticoagulation in the management of pancreatic cancer","volume":"10","author":"Sohail MA","year":"2009","journal-title":"JOP J Pancreas (Online)"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2014.22"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2015-LB-183"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05026"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.02.003"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.05.060"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00440-X"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1053"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302012000900001"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2007.04.007"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-12-0232"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1372"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-25"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.10.016"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302009000200015"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-010-9134-4"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32239"},{"key":"e_1_2_6_77_1","first-page":"4","article-title":"Leptin and its cardiovascular effects: focus on angiogenesis","author":"Tahergorabi Z","year":"2015","journal-title":"Adv Biomed Res"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7.1003"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2012.00533.x"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2008.00662.x"},{"key":"e_1_2_6_81_1","article-title":"Adipose tissue and adipokines: the association with and application of adipokines in obesity","author":"Khan M","year":"2014","journal-title":"Scientifica"},{"key":"e_1_2_6_82_1","first-page":"65","article-title":"Mechanisms linking excess adiposity and carcinogenesis promotion","volume":"5","author":"P\u00e9rez\u2010Hern\u00e1ndez AI","year":"2014","journal-title":"Front Endocrinol"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2011-1015"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01395.x"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501149200"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308671100"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2921"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.8.2442"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15046184"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0395"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2008.06.002"},{"issue":"5","key":"e_1_2_6_92_1","first-page":"326","article-title":"Lipid profiles and serum visfatin concentrations in patients with type II diabetes in comparison with healthy controls","volume":"3","author":"Hajianfar H","year":"2012","journal-title":"Int J Prev Med"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(03)00052-2"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R600021-JLR200"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986710793176339"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.03.027"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800908783769346"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.140145"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-006-9005-3"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.09112"},{"issue":"1","key":"e_1_2_6_101_1","first-page":"1","article-title":"Tumour necrosis factor\u2010alpha expression in tumour islets confers a survival advantage in non\u2010small cell lung cancer","volume":"10","author":"Ohri CM","year":"2010","journal-title":"BMC Cancer"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.01.009"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25764"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1670"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2016.4"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-015-1743-y"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08477"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S86438"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2291"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3700-z"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.11.001"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2013.06.002"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.02.048"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.306"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2785"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.4564"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2010.09.002"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2010.07.014"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101312"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.386573"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2009.11.015"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.09.016"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-7551-5_6"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1408"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.1099.13.7"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2015-1036"},{"key":"e_1_2_6_127_1","doi-asserted-by":"crossref","unstructured":"LangeCA YeeD.Progesterone and breast cancer.2008.","DOI":"10.2217\/17455057.4.2.151"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874070701610010076"},{"key":"e_1_2_6_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2004.tb02796.x"},{"key":"e_1_2_6_130_1","doi-asserted-by":"publisher","DOI":"10.1586\/eem.11.20"},{"key":"e_1_2_6_131_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2010-0031"},{"key":"e_1_2_6_132_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0179"},{"key":"e_1_2_6_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2010.08.004"},{"key":"e_1_2_6_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.10.035"},{"key":"e_1_2_6_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.02.051"},{"key":"e_1_2_6_136_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116691"},{"issue":"2","key":"e_1_2_6_137_1","first-page":"623","article-title":"Efficacy of the progesterone receptor antagonist mifepristone for palliative therapy of patients with a variety of advanced cancer types","volume":"30","author":"Check JH","year":"2010","journal-title":"Anticancer Res"},{"issue":"12","key":"e_1_2_6_138_1","first-page":"4921","article-title":"Progesterone receptor antagonist therapy has therapeutic potential even in cancer restricted to males as evidenced from murine testicular and prostate cancer studies","volume":"30","author":"Check JH","year":"2010","journal-title":"Anticancer Res"},{"key":"e_1_2_6_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2011.07.013"},{"key":"e_1_2_6_140_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2004-0027"},{"key":"e_1_2_6_141_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109659"},{"key":"e_1_2_6_142_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.9759"},{"key":"e_1_2_6_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-23998-9"},{"key":"e_1_2_6_144_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1950"},{"issue":"9","key":"e_1_2_6_145_1","first-page":"910","article-title":"Progesterone and estrogen receptor expression and activity in human non\u2010small cell lung cancer","volume":"76","author":"Marquez\u2010Garban DC","year":"2011","journal-title":"Steroids"},{"key":"e_1_2_6_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2006.02.002"},{"key":"e_1_2_6_147_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/789174"},{"key":"e_1_2_6_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2010.06.007"},{"key":"e_1_2_6_149_1","doi-asserted-by":"crossref","unstructured":"VadysirisackDD EllisenLW.mTOR activity under hypoxia. mTOR: Methods and Protocols.2012:45\u201058.","DOI":"10.1007\/978-1-61779-430-8_4"},{"key":"e_1_2_6_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/465562a"},{"key":"e_1_2_6_151_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809"},{"key":"e_1_2_6_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3504"},{"key":"e_1_2_6_153_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05039.x"},{"key":"e_1_2_6_154_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.10.11"},{"key":"e_1_2_6_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.123"},{"key":"e_1_2_6_156_1","doi-asserted-by":"crossref","unstructured":"CruzPM MoH McConathyWJ SabnisN LackoA.The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings relevant to future cancer therapeutics.2013.","DOI":"10.3389\/fphar.2013.00119"},{"key":"e_1_2_6_157_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1987211"},{"key":"e_1_2_6_158_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-14-0183"},{"key":"e_1_2_6_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604515"},{"key":"e_1_2_6_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2008.01.007"},{"key":"e_1_2_6_161_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2002.5600"},{"key":"e_1_2_6_162_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.011338"},{"key":"e_1_2_6_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(09)02002-8"},{"key":"e_1_2_6_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-011-0726-6"},{"key":"e_1_2_6_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3174"},{"issue":"10","key":"e_1_2_6_166_1","first-page":"1","article-title":"Calorie restriction and cancer prevention: a mechanistic perspective","volume":"1","author":"Hursting SD","year":"2013","journal-title":"Canc Metab"},{"key":"e_1_2_6_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2627"},{"key":"e_1_2_6_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.321"},{"key":"e_1_2_6_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.94"},{"key":"e_1_2_6_170_1","doi-asserted-by":"publisher","DOI":"10.4161\/adip.24472"},{"key":"e_1_2_6_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.122"},{"key":"e_1_2_6_172_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3442"},{"key":"e_1_2_6_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28903"},{"key":"e_1_2_6_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.11.027"},{"key":"e_1_2_6_175_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-014-9899-2"},{"key":"e_1_2_6_176_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-12-0324"},{"key":"e_1_2_6_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.05.017"},{"key":"e_1_2_6_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2010.01.005"},{"key":"e_1_2_6_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.05.005"},{"key":"e_1_2_6_180_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04565.x"},{"issue":"6","key":"e_1_2_6_181_1","first-page":"57","article-title":"Metformin in cancer prevention and therapy","volume":"2","author":"Kasznicki J","year":"2014","journal-title":"Ann Transl Med"},{"key":"e_1_2_6_182_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-33"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbf.3229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbf.3229","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.3229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:22:59Z","timestamp":1760041379000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.3229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,9]]},"references-count":181,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1002\/cbf.3229"],"URL":"https:\/\/doi.org\/10.1002\/cbf.3229","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"value":"0263-6484","type":"print"},{"value":"1099-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,9]]}}}