{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:44:56Z","timestamp":1789055096905,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T00:00:00Z","timestamp":1479254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Taiwan Department of Health, Clinical Trial and Research Center of Excellence","award":["MOHW105-TDU-B-212-113019"],"award-info":[{"award-number":["MOHW105-TDU-B-212-113019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>ZAK (sterile alpha motif and leucine zipper containing kinase AZK), a serine\/threonine kinase with multiple biochemical functions, has been associated with various cell processes, including cell proliferation, cell differentiation, and cardiac hypertrophy. In our previous reports, we found that the activation of ZAK\u03b1 signaling was critical for cardiac hypertrophy. In this study, we show that the expression of ZAK\u03b1 activated apoptosis through both a FAS\u2010dependent pathway and a mitochondria\u2010dependent pathway by subsequently inducing caspase\u20103. ZAK\u03b2, an isoform of ZAK\u03b1, is dramatically expressed during cardiac hypertrophy and apoptosis. The interaction between ZAK\u03b1 and ZAK\u03b2 was demonstrated here using immunoprecipitation. The results show that ZAK\u03b2 has the ability to diminish the expression level of ZAK\u03b1. These findings reveal an inherent regulatory role of ZAK\u03b2 to antagonize ZAK\u03b1 and to subsequently downregulate the cardiac hypertrophy and apoptosis induced by ZAK\u03b1.<\/jats:p>","DOI":"10.1002\/cbf.3234","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T23:19:50Z","timestamp":1479338390000},"page":"606-612","source":"Crossref","is-referenced-by-count":7,"title":["ZAK\u03b2 antagonizes and ameliorates the cardiac hypertrophic and apoptotic effects induced by ZAK\u03b1"],"prefix":"10.1002","volume":"34","author":[{"given":"Chien\u2010Yao","family":"Fu","sequence":"first","affiliation":[{"name":"Graduate Institute of Aging Medicine China Medical University  Taichung Taiwan"},{"name":"Orthopaedic Department Armed Forces General Hospital  Taichung Taiwan"},{"name":"Department of Emergency Medicine China Medical University Hospital  Taichung 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