{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:42:43Z","timestamp":1791895363464,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2013CB967401"],"award-info":[{"award-number":["2013CB967401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81370675"],"award-info":[{"award-number":["81370675"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>MicroRNAs (miRs) are functionally important in spermatogenesis, which is the self\u2010renewal or differentiation of spermatogonial stem cells (SSCs). Here, we report a novel role for miR\u201010b in regulating the self\u2010renewal of mouse SSCs. We showed that miR\u201010b was highly expressed in mouse SSCs in vitro and enhanced SSC proliferation. Knockdown of miR\u201010b significantly increased the apoptosis of SSCs compared with controls. Kruppel\u2010like factor 4 was found to be a target gene of miR\u201010b in the enhancement of SSC proliferation. These findings further our understanding of the self\u2010renewal and differentiation of SSCs and provide a basis for the diagnosis, treatment, and prevention of male infertility.<\/jats:p>","DOI":"10.1002\/cbf.3263","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T03:11:27Z","timestamp":1493003487000},"page":"184-191","source":"Crossref","is-referenced-by-count":27,"title":["MicroRNA\u201010b regulates the renewal of spermatogonial stem cells through Kruppel\u2010like factor 4"],"prefix":"10.1002","volume":"35","author":[{"given":"Jiang","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Hu","sequence":"additional","affiliation":[{"name":"Bio\u2010X Institutes Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng G.","family":"Tian","sequence":"additional","affiliation":[{"name":"Bio\u2010X Institutes Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhi","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuying","family":"Pei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrong","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-9783","authenticated-orcid":false,"given":"Ji","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education Ningxia Medical University  Yinchuan China"},{"name":"Bio\u2010X Institutes Shanghai Jiao Tong University  Shanghai China"},{"name":"Shanghai Key Laboratory of Reproductive Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071607"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.24.110707.175355"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-6-29"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509333103"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001738"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.109.008128"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12838"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1474"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1109987108"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.138"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-11-64"},{"key":"e_1_2_6_13_1","first-page":"625","article-title":"Expressions of a group of miRNAs during testis development and regulation effect of miR\u2010125a on development of spermatogonial stem cells","volume":"35","author":"Mei XX","year":"2015","journal-title":"J Shanghai Jiao Tong Univ Med Sci"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2009.00589.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.74.1.68"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2008.01.011"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.104.036400"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.33.20009"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3619"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2009.06.1081"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.062877"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00231-9"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1091903"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00428-8"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091354"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2015.1719"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.043"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703820104"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.06.004"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07299"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbf.3263","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.3263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:12:11Z","timestamp":1760055131000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.3263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1002\/cbf.3263"],"URL":"https:\/\/doi.org\/10.1002\/cbf.3263","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"value":"0263-6484","type":"print"},{"value":"1099-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}