{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:06:04Z","timestamp":1760141164647,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["2014NJMUZD023 to WDZ"],"award-info":[{"award-number":["2014NJMUZD023 to WDZ"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31640048 to GPZ, 81300023 to RJ"],"award-info":[{"award-number":["31640048 to GPZ, 81300023 to RJ"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Retinopathy of prematurity, a leading cause of visual impairment in low birth\u2010weight infants, remains a crucial therapeutic challenge. Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor that promotes rod and cone photoreceptor survival and cone outer segment regeneration in the degenerating retina. Ciliary neurotrophic factor expression is regulated by many factors such as all\u2010trans retinoic acid (ATRA). In this study, we found that ATRA increased CNTF expression in mouse retinal pigment epithelial (RPE) cells in a dose\u2010 and time\u2010dependent manner, and PKA signaling pathway is necessary for ATRA\u2010induced CNTF upregulation. Furthermore, we showed that ATRA promoted CNTF expression through CREB binding to its promoter region. In addition, CNTF levels were decreased in serum of retinopathy of prematurity children and in retinal tissue of oxygen\u2010induced retinopathy mice. In mouse RPE cells cultured with high oxygen, CNTF expression and secretion were decreased, but could be recovered after treatment with ATRA. In conclusion, our data suggest that ATRA administration upregulates CNTF expression in RPE cells.<\/jats:p>","DOI":"10.1002\/cbf.3264","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T10:56:47Z","timestamp":1496833007000},"page":"202-208","source":"Crossref","is-referenced-by-count":4,"title":["All\u2010trans retinoic acid upregulates the expression of ciliary neurotrophic factor in retinal pigment epithelial cells"],"prefix":"10.1002","volume":"35","author":[{"given":"Wen\u2010Di","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital Nanjing Medical University  Nanjing Jiangsu Province China"},{"name":"Department of Pediatrics, Huai'an First People's Hospital Nanjing Medical University  Huai'an Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u2010Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan\u2010Bo","family":"Zhou","sequence":"additional","affiliation":[{"name":"2013 Clinical Class 7, School of Basic Medical Sciences Nanjing Medical University  Nanjing Jiangsu, P.R. 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