{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T05:59:31Z","timestamp":1778392771278,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004006","name":"Bilimsel Ara\u015ftirma Projeleri Birimi, Istanbul \u00dcniversitesi","doi-asserted-by":"publisher","award":["Project No. 51189."],"award-info":[{"award-number":["Project No. 51189."]}],"id":[{"id":"10.13039\/501100004006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>The study aims to evaluate the effect of saxagliptin, a specific inhibitor of dipeptidyl peptidase\u20104 enzymes, on body weight gain, lipid profiles, and cell death through apoptosis in rats with insulin resistance (IR). Male adult Sprague\u2010Dawley rats (n\u00a0=\u00a032) were divided into 4 groups: control (Ctrl), IR, saxagliptin control, and IR treated with saxagliptin(IR\u00a0+\u00a0S). Insulin resistance was induced by 10% fructose in the drinking water for 8\u00a0weeks. Saxagliptin (10\u00a0mg\/kg\/day) was administrated by oral gavage for 2\u00a0weeks. Biochemical parameters were measured spectrophotometrically. Peptides were determined by the streptavidin\u2010biotin\u2010peroxidase method. Although the amount of food and liquid consumed are inversely proportional, the calories received are almost equal between both Ctrl and IR groups, as well as IR and IR\u00a0+\u00a0S groups. Increased homeostasis model assessment for insulin resistance, HOMA\u2010\u03b2, triglycerides, and very low\u2010density lipoprotein in the IR group were comparatively decreased by saxagliptin administration. The area percentage of caspase\u20103 and apoptotic peptidase activating factor\u20101 immunopositive cells in the IR\u00a0+\u00a0S group decreased compared with the IR group. Similarly, the percentages of caspase\u20108 and \u20109 immunopositive cells in the IR group were higher than the IR\u00a0+\u00a0S group. It was observed that the percentage of poly (ADP\u2010ribose) polymerase\u20101 immunopositive cells was increased in the IR\u00a0+\u00a0S group compared with the IR group. Thus, saxagliptin may prevent IR\u2010induced apoptotic cell death and regulate impaired homeostasis model assessment for insulin resistance and serum lipid levels.<\/jats:p>","DOI":"10.1002\/cbf.3333","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T00:05:49Z","timestamp":1525997149000},"page":"212-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dipeptidyl peptidase\u20104 inhibition prevents cell death via extrinsic and intrinsic apoptotic pathways in rat pancreas with insulin resistance"],"prefix":"10.1002","volume":"36","author":[{"given":"Gulay","family":"Nephan","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Cerrahpasa Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep Mine","family":"Coskun","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Arts and Sciences Istanbul Bilim University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8463-5561","authenticated-orcid":false,"given":"Sema","family":"Bolkent","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Cerrahpasa Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2011.559370"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107680609900917"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17870-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2012(07)18"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.11.014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-2-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i45.6552"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i33.4478"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.10.5.512"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.11.019"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.08.005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0631828100"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20100372"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.132"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-017-0170-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/2359-3997000000169"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2001000900008"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2017.1415938"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-10-114"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomag.2013.12.003"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-016-0074-1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/263897"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(12)70739-9"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2016.05.003"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09589"},{"key":"e_1_2_7_29_1","first-page":"1","article-title":"Effects of resveratrol on high\u2010fructose\u2010induced testis injury in rats","volume":"1","author":"Meydanli EG","year":"2017","journal-title":"Ultrastruct Pathol"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-7-82"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-017-1167-z"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9040405"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.05.032"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.06.014"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.06.008"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092840"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.58"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.074252"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1070"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.02.039"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026716"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-8-31"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C300098200"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/aob\/mcq243"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553000110069335"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbf.3333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.3333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:18Z","timestamp":1760054418000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.3333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,10]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/cbf.3333"],"URL":"https:\/\/doi.org\/10.1002\/cbf.3333","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"value":"0263-6484","type":"print"},{"value":"1099-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,10]]},"assertion":[{"value":"2018-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}