{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:54:52Z","timestamp":1784289292555,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>Classical Hodgkin lymphoma (cHL) is a particular kind of malignant tumour that originates from the B cells. The malignant phenotype of cHL is, at least in part, maintained by epigenetic aberrations, which primarily consist of abnormal histone methylation and acetylation. Progress has been made in clinical trials concerning the histone deacetylases inhibitors (HDACis) in cHL. Also, some demethylation regimens could serve the purpose of preventing and treating tumours. Programmed death\u2010ligand receptor 1 (PD\u2010L1, CD274) inhibitors or apoptosis receptor 1 (PD\u20101, CD279) inhibitors are used in treating patients with relapsed cHL in recent years. Academic researches indicated that PD\u20101\/PD\u2010L1 inhibitors, including nivolumab and pembrolizumab, demonstrate remarkable activity in relapsed cHL. In addition, in recent years, a close association between epigenetic aberrations and immune escape has been explored in cHL. DNA methyltransferase (DNMT) inhibitors, HDACis, and immune checkpoint blockade exhibit synergistic effects. Thus, this review aims to provide an overview on the epigenetic abnormalities of cHL and its effect on immune escape, in order to explore the optimal combination approach to treat the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance of the study<\/jats:title><jats:p>Cancer Statistics 2018 reported that more than 8000 new cases of Hodgkin lymphoma were diagnosed. In recent years, PD\u20101\/PD\u2010L1 inhibitors for cHL have been utilized, and the therapeutic strategies of HDACis combined with PD\u20101\/PD\u2010L1 inhibitors have been raised. It is critical for improving the efficacy and decreasing the toxicity in treating the patients with cHL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbf.3463","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T04:29:37Z","timestamp":1573446577000},"page":"242-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Epigenetic abnormalities of classical Hodgkin lymphoma and its effect on immune escape"],"prefix":"10.1002","volume":"38","author":[{"given":"Yizhen","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renhong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery of Changzheng Hospital 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