{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:06:01Z","timestamp":1771473961111,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>LncRNA <jats:italic>LINC\u2010PINT<\/jats:italic> acts as an important regulator in the development of many cancers. The current study aimed to explore the role of <jats:italic>LINC\u2010PINT<\/jats:italic> in the progression of ovarian cancer (OC). <jats:italic>LINC\u2010PINT<\/jats:italic> expression level in different FIGO stages of OC and its adjacent tissues, normal HOSE and OC cell lines (A2780, SKOV3, OVCAR3 and HO\u20108910) was determined by qRT\u2010PCR. Survival analysis on <jats:italic>LINC\u2010PINT<\/jats:italic> and OC patients was conducted by Kaplan\u2010Meier. CCK\u20108, flow cytometry, wound\u2010healing, Transwell assays and western blot were performed to detect the effects of <jats:italic>LINC\u2010PINT<\/jats:italic> on proliferation, apoptosis, migration, invasion and EMT process in OC cells. Target gene of <jats:italic>LINC\u2010PINT<\/jats:italic> was predicted by Starbase and verified by dual\u2010luciferase reporter assay. The expression of miR\u2010374a\u20105p in normal and OC tissues, <jats:italic>LINC\u2010PINT<\/jats:italic>\u2010 or si<jats:italic>LINC\u2010PINT<\/jats:italic>\u2010modified OC cells was determined. Moreover, rescue assay was carried out to confirm whether <jats:italic>LINC\u2010PINT<\/jats:italic> contributes to the development of OC cells through targeting miR\u2010374a\u20105p. Low expression of <jats:italic>LINC\u2010PINT<\/jats:italic> was observed in OC tissues and cells, noticeably, <jats:italic>LINC\u2010PINT<\/jats:italic> expression was even lower in OC tissues with higher FIGO stage. Increased <jats:italic>LINC\u2010PINT<\/jats:italic> expression significantly inhibited cell proliferation, promoted apoptosis and suppressed migration, invasion and EMT process, while silencing of <jats:italic>LINC\u2010PINT<\/jats:italic> caused the opposite results. Moreover, <jats:italic>LINC\u2010PINT<\/jats:italic> sponged miR\u2010374a\u20105p and overexpressed miR\u2010374a\u20105p attenuated the effect of up\u2010regulated <jats:italic>LINC\u2010PINT<\/jats:italic> on cell viability, migration, invasion and apoptosis. <jats:italic>LINC\u2010PINT<\/jats:italic> acts as a tumour suppressor, as it could inhibit cell proliferation, migration, invasion and EMT process, and promote cell apoptosis through down\u2010regulating miR\u2010374a\u20105p.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance of the study<\/jats:title><jats:p>Ovarian cancer (OC), which is a frequently diagnosed tumour in female reproductive organs, has a high incidence rate behind cervical cancer and endometrial cancer. LncRNA <jats:italic>LINC\u2010PINT<\/jats:italic> acts as an important regulator in the development of many cancers. The current study aimed to explore the role of <jats:italic>LINC\u2010PINT<\/jats:italic> in the progression of ovarian cancer (OC) and found that <jats:italic>LINC\u2010PINT<\/jats:italic> inhibited cell proliferation, migration invasion and EMT process of OC cell via regulating miR\u2010374a\u20105p; it might be a potential target for OC treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbf.3565","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T02:30:37Z","timestamp":1594175437000},"page":"1089-1099","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["<scp><i>LINC\u2010PINT<\/i><\/scp> suppresses tumour cell proliferation, migration and invasion through targeting <scp>miR<\/scp>\u2010374a\u20105p in ovarian cancer"],"prefix":"10.1002","volume":"38","author":[{"given":"Ting","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Pathology Heze Municipal Hospital  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