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Recent studies have shown that the receptor by which 1\u03b1,25\u2010dihydroxyvitamin D\n                    <jats:sub>3<\/jats:sub>\n                    (1,25[OH]\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    ) exerts its biological actions (ie, the vitamin D receptor, VDR) elicits both genomic and non\u2010genomic effects upon skeletal muscle. The controversy surrounding skeletal muscle VDR mRNA\/protein expression in post\u2010natal muscle has been allayed by myriad recent studies, while dynamic expression of VDR throughout myogenesis, and association of higher VDR levels during muscle regeneration\/immature muscle cells, suggests a role in myogenesis and perhaps an enrichment of VDR in satellite cells. Accordingly, in vitro studies have demonstrated 1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    is anti\u2010proliferative in myoblasts, yet pro\u2010differentiation in latter stages of myogenesis. These effects involve modulation of gene expression (VDR as a transcriptional co\u2010activator controls ~3% of the genome) and post\u2010genomic intracellular signalling for example, via c\u2010Src and alterations to intramuscular calcium homeostasis and proteostasis. The aim of this review is to consider the biomolecular role for the vitamin D\/VDR axis in myogenesis, while also exploring global evidence for genomic and non\u2010genomic mechanisms of action for 1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    \/VDR.\n                  <\/jats:p>","DOI":"10.1002\/cbf.3595","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T01:39:12Z","timestamp":1602293952000},"page":"48-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Myogenic, genomic and non\u2010genomic influences of the vitamin D axis in skeletal muscle"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3687-9948","authenticated-orcid":false,"given":"Shelby E.","family":"Bollen","sequence":"first","affiliation":[{"name":"MRC\/ARUK Centre for Musculoskeletal Ageing Research and National Institute for Health Research (NIHR), Nottingham Biomedical Research Centre (BRC), School of Medicine University of Nottingham  Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7286-046X","authenticated-orcid":false,"given":"Philip J.","family":"Atherton","sequence":"additional","affiliation":[{"name":"MRC\/ARUK Centre for Musculoskeletal Ageing Research and National Institute for Health Research (NIHR), Nottingham Biomedical Research Centre (BRC), School of Medicine University of Nottingham  Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_2_5_3_1","first-page":"118","article-title":"Vitamin D: the sunshine vitamin","volume":"3","author":"Nair R","year":"2012","journal-title":"J Pharmacol Pharmacother"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2014.01.011"},{"key":"e_1_2_5_5_1","unstructured":"NICE. 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