{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:56Z","timestamp":1786977356806,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>\n                    S100 calcium binding protein A6 (S100A6) has been reported to involve in many kinds of cancers through regulating intracellular calcium homeostasis. Previous studies found that S100A6 increased in lung cancer patients' plasma and pleural effusion. This study focused on its function in Calu\u20106 lung cancer cells. S100A6 gene was transferred into Calu\u20106 lung cancer cell line by lentivirus vector, the empty vector transfected cells and the blank cells were set as control groups. MTT was evaluating cell proliferation. The transwell assay was reflecting cell migration and cell invasion. The flow cytometric analysis was detecting cell apoptosis and cell cycle of three groups (Calu\u20106, Calu\u20106\/neo, Calu\u20106\/S100A6). Nude mouse tumorigenicity was then applied to evaluate S100A6's effect on cellular tumorigenicity. Compared with control groups, Calu\u20106\/S100A6 cells showed a weakening trend in the cell behaviours of proliferation, migration and invasiveness, while had an enhancement of cell apoptosis, with all\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.05. The cell cycle of Calu\u20106\/S100A6 cells had a reduction of S phase and an increase of G1 phase (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.05). In animal study, after 5\u2009weeks of cell injection, the tumour bulk of Calu\u20106\/S100A6 group was smaller than controls, with\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.05. Our results demonstrate S100A6 inhibits the growth of Calu\u20106 lung cancer cells, as well as impairs Calu\u20106's ability in tumorigenesis. At cellular level, S100A6 is supposed to act as a tumour suppressor gene in lung cancer.\n                  <\/jats:p>","DOI":"10.1002\/cbf.3639","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T23:39:30Z","timestamp":1621381170000},"page":"771-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<scp>S100A6<\/scp>\n                    represses Calu\u20106 lung cancer cells growth via inhibiting cell proliferation, migration, invasion and enhancing apoptosis"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-6796","authenticated-orcid":false,"given":"Ting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Xi'an People's Hospital (Xi'an No.4 Hospital)  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suoli","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Oncology Zibo Mining Coal Hospital  Zibo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Center for Elderly Beijing Rehabilitation Hospital Affiliated to Capital Medical University  Beijing 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promotes the proliferation and migration of cervical cancer cells via the PI3K\/Akt signaling pathway","volume":"15","author":"Li A","year":"2018","journal-title":"Oncol Lett"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.5419"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0714"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22563"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39786"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02417.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.904279"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.06.003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2011.02783.x"},{"key":"e_1_2_7_23_1","first-page":"4634","article-title":"S100A6\/miR193a regulates the proliferation, invasion, migration and angiogenesis of lung cancer cells through the P53 acetylation","volume":"11","author":"Li P","year":"2019","journal-title":"Am J Transl Res"},{"key":"e_1_2_7_24_1","first-page":"7999","article-title":"Diminished expression of S100A2, a putative tumor suppressor, at early stage of human lung carcinogenesis","volume":"61","author":"Feng G","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205979"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602188"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2008_3062"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.08.007"}],"container-title":["Cell Biochemistry and 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