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C57 mice, aged 4\u2009weeks, were injected intraperitoneally in the KA group with 20\u2009mg\/kg of KA and in the sham experimental group with normal saline. The whole brain and hippocampus of mice in the sham experimental group and KA epilepsy model group were collected on days 7, 14, 21 and 28 after injection. The difference in the protein expression in the hippocampus was detected using fluorescence immunohistochemistry. The hippocampal tissue was also collected and frozen to detect protein expression by western blot. The results of the haematoxylin and eosin (HE) and Nissl staining showed that the mouse model of temporal lobe epilepsy could be established by intraperitoneal injection of KA, and the success rate of the model was 53.8%. The expression of DCX\u2010, \u03b2\u2010catenin\u2010, GFAP\u2010 and Iba\u20101\u2010labelled glial cells in the KA\u2010induced epilepsy model group were higher than those in the sham group. The\u00a0results of western blotting showed that the expression of DCX and \u03b2\u2010catenin in the KA\u2010induced epilepsy model group was higher than that in the sham experimental group, while the expression of N\u2010cadherin and Iba\u20101 on days 14 and 28 was significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) higher than that in the sham experimental group. In KA\u2010induced epilepsy model group, the expression of Bcl\u20102 was decreased, while the expression of Bad and PUMA was increased.<\/jats:p>","DOI":"10.1002\/cbf.3651","type":"journal-article","created":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T21:55:08Z","timestamp":1622411708000},"page":"791-801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Abnormal neuronal damage and inflammation in the hippocampus of kainic acid\u2010induced epilepsy mice"],"prefix":"10.1002","volume":"39","author":[{"given":"Xiaoying","family":"Li","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Gansu Agricultural University  Lanzhou Gansu China"},{"name":"Stem Cells &amp; Biotherapy Engineering Research Center of Henan College of Life Science and Technology, Xinxiang Medical University  Xinxiang 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