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Nowadays, alteration of gene expression is an important way to improve the performance of MSCs in the clinic. MicroRNAs (miRs) and CD200 are known to modulate the immune system in MSCs. Curcumin is famous for its anti\u2010inflammatory impacts. Phytosomal curcumin (PC) is a nanoparticle synthesized from curcumin that removes the drawbacks of curcumin. The purpose of this research was to assess the effects of PC on the expression of the CD200 and four key miRNAs in immune system. PC (30\u2009\u03bcM) treatment of hDPSCs could ameliorate their immunoregulatory property, presented by reduced expressions of miR\u201021, miR\u2010155 and miR\u2010126, as well as enhanced expressions of miR\u201023 and CD200. The PC was also able to reduce PI3K\\AKT1\\NF\u2010\u03baB expressions that were target genes for these miRs and involved in inflammatory pathways. Moreover, PC was more effective than curcumin in improving the immune modulation of hDPSCs. Evidence in this study suggested that PC mediates immunoregulatory activities in hDPSC via miRs and CD200 to regulate PI3K\\AKT1\\NF\u2010\u03baB signalling pathways, which may provide a theoretical basis for PC in the treatment of many diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance of the study<\/jats:title><jats:p>Autoimmune diseases or tooth caries are partly attributed to global health problems and their common drug treatments have several side effects. The goal of this study is dentin regeneration and autoimmune diseases treatment via stem cell\u2010based approaches with phytosomal curcumin (PC), for the first time. Because dental pulp stem cells have unique advantages (including higher immunomodulatory capacity) over other mesenchymal stem cells, we considered them the best option for treating these diseases. Using PC, we try to increase the immunomodulatory properties of these cells.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbf.3659","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T20:10:34Z","timestamp":1625688634000},"page":"886-895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Immunomodulatory effects of phytosomal curcumin on related\u2010micro <scp>RNAs<\/scp>, <scp>CD200<\/scp> expression and inflammatory pathways in dental pulp stem cells"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1285-7955","authenticated-orcid":false,"given":"Malaksima","family":"Ayadilord","sequence":"first","affiliation":[{"name":"Student Research Committee Birjand University of Medical Sciences  Birjand Iran"},{"name":"Department of Immunology, Faculty of Medicine Birjand University of Medical Sciences  Birjand 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