{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:25:07Z","timestamp":1790623507887,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and involvement of the synovial membrane, causing joint damage and deformities. No effective drug treatment is available, and physical exercise has been utilized to alleviate the inflammatory processes. This study aimed to investigate the effects of different exercise training protocols on Zymosan\u2010induced RA inflammatory markers in the right knee of Wistar rats. The rodents were subjected to aerobic, resisted, and combined physical training protocols with variations in the total training volume (50% or 100% of resistance and aerobic training volume) for 8 weeks. All physical training protocols reduced cachexia and systemic inflammatory processes. The histological results showed an increase in the inflammatory influx to the synovial tissue of the right knee in all physical training protocols. The rats that underwent combined physical training with reduced volume had a lower inflammatory influx compared to the other experimental groups. A reduction in the mRNA expression of inflammatory genes and an increase in anti\u2010inflammatory gene expression were also observed. The physical training protocol associated with volume reduction attenuated systemic and synovial inflammation of the right knee, reducing the impact of Zymosan\u2010induced RA in rats.<\/jats:p>","DOI":"10.1002\/cbf.3697","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T09:45:41Z","timestamp":1647510341000},"page":"321-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of different physical training protocols on inflammatory markers in Zymosan\u2010induced rheumatoid arthritis in Wistar rats"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2056-8384","authenticated-orcid":false,"given":"Robson","family":"Damasceno de Lima","sequence":"first","affiliation":[{"name":"Graduate Program in Biomedical Sciences Centro Universit\u00e1rio Herm\u00ednio Ometto\u2014UNIARARAS Araras S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-5761","authenticated-orcid":false,"given":"Matheus","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Graduate Program in Biomedical Sciences Centro Universit\u00e1rio Herm\u00ednio Ometto\u2014UNIARARAS Araras S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-3603","authenticated-orcid":false,"given":"Fernando Russo","family":"Costa do Bomfim","sequence":"additional","affiliation":[{"name":"Graduate Program in Biomedical Sciences Centro Universit\u00e1rio Herm\u00ednio Ometto\u2014UNIARARAS Araras S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4177-8735","authenticated-orcid":false,"given":"Gabriela Bortolan\u00e7a","family":"Chiarotto","sequence":"additional","affiliation":[{"name":"Graduate Program in Biomedical Sciences Centro Universit\u00e1rio Herm\u00ednio Ometto\u2014UNIARARAS Araras S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4116-870X","authenticated-orcid":false,"given":"Paulo Henrique","family":"Canciglieri","sequence":"additional","affiliation":[{"name":"Herm\u00ednio Ometto University Center\u2014UNIARARAS Araras S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-1521","authenticated-orcid":false,"given":"Jos\u00e9 Rodrigo","family":"Pauli","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise University of Campinas (UNICAMP) Limeira S\u00e3o Paulo Brazil"},{"name":"OCRC\u2014Obesity and Comorbidities Research Center University of Campinas (UNICAMP) Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-2831","authenticated-orcid":false,"given":"Ma\u00edra","family":"Felonato","sequence":"additional","affiliation":[{"name":"Graduate Program in Biomedical Sciences Centro Universit\u00e1rio Herm\u00ednio Ometto\u2014UNIARARAS Araras S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"347","article-title":"One year in review 2019: pathogenesis of rheumatoid arthritis","volume":"37","author":"Croia C","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2019.03.013"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(02)00237-1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12280"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740802055984"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken146"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211649"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01958"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2018.02.010"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213585"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","unstructured":"LawR\u2010J SaynorZL GabbitasJ et al. The Effects of Aerobic and Resistance Exercise on Markers of Large Joint Health in Stable Rheumatoid Arthritis Patients: A Pilot Study.2015.doi:10.1002\/msc.1103","DOI":"10.1002\/msc.1103"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202075"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/205691"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2015.09.022"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.06.007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-019-04483-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jan.14574"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/msc.1028"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000564"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11062-016-9577-7"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","unstructured":"Janu\u00e1rio dos AnjosLM daFonsecaAdS GameiroJ dePaoliFLow\u2010intensity infrared laser effects on zymosan\u2010induced articular inflammatory response. In:JansenED(ed).Optical Interactions with Tissue and Cells XXVI.2015 p932114.","DOI":"10.1117\/12.2079785"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(94)00243-X"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1647"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2541-6"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-006-0396-8"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1139\/h95-031"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367707779399518"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511006301"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.057"},{"key":"e_1_2_10_31_1","article-title":"Lasertherapy as A Strategy for Treatment Healing under Caloric Restriction\u2014Study in Rats","volume":"6","author":"Moscardi LC","year":"2018","journal-title":"J Pharm Pharmacol"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2004001200018"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1517-86922012000600014"},{"key":"e_1_2_10_35_1","first-page":"61","article-title":"Respostas metab\u00f3licas agudas de ratos Wistar ao exerc\u00edcio intermitente de saltos","volume":"10","author":"Rogatto GP","year":"2004","journal-title":"Motriz"},{"key":"e_1_2_10_36_1","unstructured":"SpagnolAR MalheiroOCDM CastoldiRC et al. An\u00e1lise da plasticidade muscular de ratos submetidos a um protocolo de treinamento f\u00edsico concorrente.\u00a02012;20:118\u2010124."},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11466"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181f1bf0d"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21514"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e3180616b27"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-015-0363-2"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209775"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00562.2005"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-04937-4"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23589"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-019-04384-8"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203291"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181b11ab7"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13204"},{"key":"e_1_2_10_50_1","first-page":"175","article-title":"Review One year in review 2018: pathogenesis of rheumatoid arthritis","volume":"36","author":"Calabresi E","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29228"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14417"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-021-00714-w"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00353"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194331"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2018.11.015"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242648"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.11.010"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41065-020-00169-3"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200002000-00011"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.6063\/motricidade.7941"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21856-2"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/1099800420958068"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.2535\/ofaj.93.81"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8121493"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.3697","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbf.3697","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.3697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:23:50Z","timestamp":1760275430000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.3697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,17]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/cbf.3697"],"URL":"https:\/\/doi.org\/10.1002\/cbf.3697","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"value":"0263-6484","type":"print"},{"value":"1099-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,17]]},"assertion":[{"value":"2021-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}