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Genetic factors are important pathogenic factors of epilepsy, such as epilepsy caused by protocadherin\u201019 (PCDH\u201019) mutation, which is an X\u2010linked genetic disease. It is more common in female heterozygotes, which are caused by mutations in the PCDH\u201019 gene. Epilepsy caused by environmental factors is mainly caused by brain injury, which is commonly caused by brain tumors, brain surgery, or trauma to the brain. In addition, the pathogenesis of epilepsy is closely related to abnormalities in some signaling pathways. The Wnt\/\u03b2\u2010catenin signaling pathway is considered a new target for the treatment of epilepsy. This review summarizes these factors inducing epilepsy and the research hypotheses regarding the pathogenesis of epilepsy. The focus of this review centers on cadherins and the pathogenesis of epilepsy. We analyzed the pathogenesis of epilepsy induced by N\u2010cadherin and PCDH\u201019 in the cadherin family members. 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