{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:23:43Z","timestamp":1787063023899,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Several biological activities of the fungal exopolysaccharide (1\u2009\u2192\u20093)(1\u2009\u2192\u20096)\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010\n                    <jats:sc>d<\/jats:sc>\n                    \u2010glucan (botryosphaeran) have been described in the literature, but its effects on inflammation have not been evaluated. This study aimed to investigate the action of botryosphaeran on experimental mice models of carrageenan\u2010induced acute pleurisy and acute paw edema, and complete Freund's adjuvant\u2010induced persistent paw edema. All botryosphaeran doses tested (1.0, 2.5, 5.0, and 10.0\u2009mg\/kg birth weight [b.w.], orally administered) reduced leukocyte recruitment, nitric oxide (NO) levels, and protein extravasation in the pleural cavity. Botryosphaeran (5\u2009mg\/kg b.w.) did not diminish edema and mechanical hyperalgesia in the paw within 4\u2009h; however, cold allodynia was alleviated within the first 2\u2009h. In the persistent paw inflammation model, the effects of daily oral administration of botryosphaeran (5\u2009mg\/kg b.w.) were evaluated over 3 and 7 days. The fungal \u03b2\u2010glucan significantly reduced the levels of the cytokines, tumor necrosis factor(TNF)\u2010\u03b1, interleukin (IL)\u20106), and IL\u201010, in the paw homogenates in both protocols, while paw edema and the levels of advanced oxidation protein products (AOPP) only diminished on Day 7. No effect in mechanical hyperalgesia was observed. Oral treatment for 3 or 7 days also decreased the plasma levels of NO, AOPP, TNF\u2010\u03b1, and IL\u201010. On Day 7, the number of leukocytes in the blood was also reduced by this treatment. Importantly, botryosphaeran did not induce inflammation in mice when administered alone over 7 days. This study demonstrated the anti\u2010inflammatory and antinociceptive potential of botryosphaeran in these experimental models, making this fungal \u03b2\u2010glucan a new possibility for complementary treating acute and chronic inflammation.\n                  <\/jats:p>","DOI":"10.1002\/cbf.3727","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T09:45:50Z","timestamp":1657014350000},"page":"578-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oral administration of botryosphaeran [(1\u2009\u2192\u20093)(1\u2009\u2192\u20096)\u2010\n                    <i>\u03b2<\/i>\n                    \u2010\n                    <scp>d<\/scp>\n                    \u2010glucan] reduces inflammation through modulation of leukocytes and has limited effect on inflammatory nociception"],"prefix":"10.1002","volume":"40","author":[{"given":"Nubia A.","family":"Silva","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias da Sa\u00fade Universidade Federal da Grande Dourados Dourados Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca G.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias da Sa\u00fade Universidade Federal da Grande Dourados Dourados Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce A.","family":"Santos","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias da Sa\u00fade Universidade Federal da Grande Dourados Dourados Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via A.","family":"Guarnier","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral, Centro de Ci\u00eancias Biol\u00f3gicas Universidade Estadual de Londrina Londrina Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneli M.","family":"Barbosa\u2010Dekker","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Centro de Ci\u00eancias Exatas Universidade Estadual de Londrina Londrina Paran\u00e1 Brazil"},{"name":"Beta\u2010Glucan Produtos Farmoqu\u00edmicos EIRELI, Lote 24A, Bloco Zirc\u00f4nia Universidade Tecnol\u00f3gica Federal do Paran\u00e1 Londrina Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F. 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