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Chronic hyperglycemia induces aberrant autophagy and promotes cellular death as a main underlying cause of diabetes\u2010related complications. Therefore, autophagy\u2010modifying therapy may be of value to prevent the development of complications. Sodium\u2010glucose cotransporter 2 inhibitors (SGLT2is) are a class of newly introduced antidiabetic drugs that achieve normoglycemia through causing overt glycosuria. 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