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The concentration of AM (3.38\u2009mg\/kg) obtained by quantitative purification from AM fruit showed the highest antioxidant activity (AOA) in vitro and was used for oral ingestion. In addition to high AOA, high values of total phenols (85.334\u2009mg\/g), total phenolic acid (606.95\u2009mg\/g), total flavonids (22.10\u2009mg\/g), and total anthocyanins (11.01\u2009mg\/g) were recorded in chokeberry extract. CCl<jats:sub>4<\/jats:sub> treatment caused serious liver injury, hepatocyte and blood cell impairment. AM extract given to rats before CCl<jats:sub>4<\/jats:sub> application had a moderate hepatoprotective effect in comparison to after CCl<jats:sub>4<\/jats:sub> application. White blood count and leukocytes were significantly altered by CCl4, however, the protective role of AM in leukocyte disorders was not established. A high number of microcytes, stomatocytes, anisocytes, and hemolyzed erythrocytes during CCl<jats:sub>4<\/jats:sub> exposure was reduced by AM extract. Flower erythrocytes in the AM\u2009+\u2009CCl<jats:sub>4<\/jats:sub> group were recorded. Supplementation with chokeberry extract without CCl<jats:sub>4<\/jats:sub> caused hyperproteinemia and hyperalbuminemia. Although the results indicate a weak protective role for AM, it is nevertheless important for improved erythropoiesis and regulation of the development of anemia. The hepatoprotective role of AM was moderate, and the immune response was not proven. Daily consumption of chokeberry extract can improve health. However, the results of our study showed that the ingestion of AM extract at this dose with the highest AOA would have more effective effects if the supplementation were significantly increased.<\/jats:p>","DOI":"10.1002\/cbf.3829","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T01:16:10Z","timestamp":1690420570000},"page":"801-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of dietary supplementation with chokeberry (<i>Aronia melanocarpa<\/i>, Michx.) on tetrachloride\u2010induced liver injury in Wistar rats: Hematological and biochemical implication"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8854-7478","authenticated-orcid":false,"given":"Damir","family":"Suljevi\u0107","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science University of Sarajevo Sarajevo Bosnia and 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