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In this current study, we investigated the protective effect of <jats:italic>C. vettiveroides<\/jats:italic> ethanolic root extract (CVERE) against thioacetamide (TAA)\u2010induced acute liver injury in rats. A single dose of TAA (300\u2009mg\/kg, b.w., i.p.) was administered to induce acute liver injury. The treatment groups of rats were concurrently treated with CVERE (125 and 250\u2009mg\/kg, b.w., p.o.) and silymarin (100\u2009mg\/kg, b.w., p.o.), respectively. After 24\u2009h of the experimental period, TAA\u2010induced liver injury was confirmed by increased activity of serum transaminases and malondialdehyde levels in liver tissue, decreased levels of antioxidants, upregulated expression of the inflammatory marker gene, and altered liver morphology. Whereas CVERE simultaneous treatment inhibited hepatic injury and prevented the elevation of serum aspartate and alanine transaminases, alkaline phosphatase, and lactate dehydrogenase activities. CVERE attenuated TAA\u2010induced oxidative stress by suppressing lipid peroxidation and restoring antioxidants such as superoxide dismutase, catalase, and reduced glutathione. Further, CVERE treatment was found to inhibit nuclear factor \u03baB\u2010mediated inflammatory signaling, as indicated by downregulated pro\u2010inflammatory cytokines including tumor necrosis factor\u2010\u03b1 and interleukin\u20101\u03b2. Our findings suggest that CVERE prevents TAA\u2010induced acute liver injury by targeting oxidative stress and inflammation.<\/jats:p>","DOI":"10.1002\/cbf.3839","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T06:14:46Z","timestamp":1692684886000},"page":"876-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<i>Coleus vettiveroides<\/i> ethanolic root extract protects against thioacetamide\u2010induced acute liver injury in rats"],"prefix":"10.1002","volume":"41","author":[{"given":"Kadmad Abdul Hameed","family":"Mohamed Azar","sequence":"first","affiliation":[{"name":"Department of Pharmacology Koppal Institute of Medical Sciences  Koppal Karnataka 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Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mani","family":"Uthirappan","sequence":"additional","affiliation":[{"name":"Animal House Division CSIR\u2010Central Leather Research Institute, Adyar  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.09.014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136777"},{"issue":"6","key":"e_1_2_9_4_1","first-page":"85","article-title":"The etiology, diagnosis and prevention of liver cirrhosis","volume":"110","author":"Wiegand J","year":"2013","journal-title":"Dtsch Arztebl 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