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While first and second\u2010generation delivery systems, such as lipoplexes (50\u2013150\u2009nm) and quantum dots,\u00a0hold immense potential in revolutionizing disease treatment through spatiotemporal controlled drug delivery, their therapeutic efficacy is restricted by the selective labeling of nanoparticles for uptake by\u00a0reticuloendothelial system\u00a0and\u00a0mononuclear phagocyte system\u00a0via various molecular forces, such as electrostatic, hydrophobic, and van der Waals bonds. This review article presents novel insights into surface\u2010modification techniques utilizing macromolecule\u2010mediated approaches, including PEGylation, di\u2010block copolymerization,\u00a0and multi\u2010block polymerization.\u00a0These techniques induce stealth properties by generating steric forces to repel micromolecular\u2010opsonins, such as fibrinogen, thereby mitigating opsonization effects. 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Future integration of artificial intelligence\u2010based algorithms, integrated with nanoparticle properties such as shape, size, and surface chemistry, can aid in elucidating nanoparticulate\u2010surface morphology and predicting interactions with the immune system, providing valuable insights into the probable path of opsonization.<\/jats:p>","DOI":"10.1002\/cbf.3880","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T01:30:50Z","timestamp":1699320650000},"page":"1031-1043","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Evasion of opsonization of macromolecules using novel surface\u2010modification and biological\u2010camouflage\u2010mediated techniques for next\u2010generation drug delivery"],"prefix":"10.1002","volume":"41","author":[{"given":"Parth","family":"Mehta","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management SVKM'S Narsee Monjee Institute of Management Studies (NMIMS) Deemed\u2010to\u2010be\u2010University Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8144-7645","authenticated-orcid":false,"given":"Pravin","family":"Shende","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management SVKM'S Narsee Monjee Institute of Management Studies (NMIMS) Deemed\u2010to\u2010be\u2010University Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00289-019-02924-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-19-8050-3_3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-11523-3_3"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00600-w"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2015.06.006"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20220045"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.10.010"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(76)90256-1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-005718"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.12.039"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2022.2129604"},{"key":"e_1_2_11_13_1","article-title":"Nanoparticles escaping RES and endosome","volume":"2011","author":"Huang L","year":"2011","journal-title":"J Nanomater"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104163"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3330"},{"key":"e_1_2_11_16_1","unstructured":"NaikU(2020). 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