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With expansion of COVID\u201019 and SARS\u2010CoV\u20102 research, correlative liver injury has been revealed. It is speculated that COVID\u201019 patients exhibited abnormal liver function, as previously observed in the SARS and MERS pandemics. Furthermore, patients with underlying diseases such as chronic liver disease are more susceptible to SARS\u2010CoV\u20102 and indicate a poor prognosis accompanied by respiratory symptoms, systemic inflammation, or metabolic diseases. Therefore, COVID\u201019 has the potential to impair liver function, while individuals with preexisting liver disease suffer from much worse infected conditions. COVID\u201019 related liver injury may be owing to direct cytopathic effect, immune dysfunction, gut\u2212liver axis interaction, and inappropriate medication use. However, discussions on these issues are infancy. Expanding research have revealed that angiotensin converting enzyme 2\u00a0(ACE2) expression mediated the combination of virus and target cells, iron metabolism participated in the virus life cycle and the fate of target cells, and amino acid metabolism regulated immune response in the host cells, which are all closely related to liver health. Further exploration holds great significance in elucidating the pathogenesis, facilitating drug development, and advancing clinical treatment of COVID\u201019\u2010related liver injury. 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