{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:42:27Z","timestamp":1792320147658,"version":"4.4.0"},"reference-count":67,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007654","name":"University of Agriculture, Faisalabad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007654","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polystyrene microplastics (PS\u2010MPs) are environmental contaminants due to their potential to induce damages in multiple organs specifically liver. Tamarixetin (TMT) is a naturally occurring flavonoid present in <jats:italic>Tamarix ramosissima<\/jats:italic> plant that exhibits multiple pharmacological properties. Therefore, the present research was designed to evaluate the palliative role of TMT against PS\u2010MPs instigated liver dysfunction in rats. The exposure to PS\u2010MPs reduced the expressions of nuclear factor erythroid 2\u2010related factor 2\u00a0and antioxidant genes, while increasing the expression of Kelch\u2010like ECH\u2010associated protein 1. PS\u2010MPs exposed rats exhibited considerably (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) higher alkaline phosphatase (ALP), aspartate aminotransferase (AST) as well as alanine aminotransferase (ALT) contents. Additionally, PS\u2010MPs treatment resulted in a notable decrease in anti\u2010oxidants activity, that is, glutathione S\u2010transferase (GST), superoxide dismutase (SOD), heme oxygenase\u20101 (HO\u20101), glutathione reductase (GSR), glutathione peroxidase (GPx), catalase (CAT) and glutathione (GSH) content, whereas upregulating reactive oxygen species (ROS) and malondialdehyde (MDA) contents. Moreover, PS\u2010MPs intoxication noticeably increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) the inflammatory indices (interleukin\u20101\u00df [IL\u20101\u00df],\u00a0nuclear factor kappa B [NF\u2010\u03baB], interleukin\u20106 [IL\u20106], tumor necrosis factor\u2010\u03b1 [TNF\u2010\u03b1] levels, and cyclooxygenase\u20102 [COX\u20102] activity). Besides, Caspase\u20103 and Bax expressions were upregulated and Bcl\u20102 expression was decreased after PS\u2010MPs exposure. Additionally, the histomorphological examination revealed notable hepatic damage in PS\u2010MPs treated group. However, TMT treatment substantially (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) recovered all the PS\u2010MPs\u2010induced damages and histopathological changes. Taken together, it can be deduced that TMT might be used as a pharmacological agent to ameliorate hepatic damage.<\/jats:p>","DOI":"10.1002\/cbf.3885","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T19:11:36Z","timestamp":1701112296000},"page":"1451-1461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Attenuative effects of tamarixetin against polystyrene microplastics\u2010induced hepatotoxicity in rats by regulation of Nrf\u20102\/Keap\u20101 pathway"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-5364","authenticated-orcid":false,"given":"Muhammad Umar","family":"Ijaz","sequence":"first","affiliation":[{"name":"Department of Zoology, Wildlife and Fisheries University of Agriculture Faisalabad 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