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Researchers are investigating the therapeutic potential of ferroptosis, a type of iron\u2010dependent controlled cell death, in the context of CRC. Curcumin, a natural compound found in turmeric, exhibits anticancer properties. This study explores the effects of curcumin on genes related to ferroptosis (FRGs)\u00a0in CRC. To gather CRC data, we used the Gene Expression Profiling Interactive Analysis (GEPIA)\u00a0and Gene Expression Omnibus (GEO)\u00a0databases, while FRGs were obtained from the FerrDb database and PubMed. We identified 739 CRC differentially expressed genes (DEGs)\u00a0in CRC and discovered 39 genes that were common genes between FRGs and CRC DEGs. The DEGs related to ferroptosis were enriched with various biological processes and molecular functions, including the regulation of signal transduction and glucose metabolism. Using the Drug Gene Interaction Database (DGIdb),\u00a0we predicted drugs targeting CRC\u2010DEGs\u00a0and identified 17 potential drug targets. Additionally, we identified eight essential proteins related to ferroptosis in CRC, including MYC, IL1B, and SLC1A5. Survival analysis revealed that alterations in gene expression of CDC25A, DDR2, FABP4, IL1B, SNCA, and TFAM were associated with prognosis in CRC patients. In SW480 human CRC cells, treatment with curcumin decreased the expression of MYC, IL1B, and EZH2 mRNA, while simultaneously increasing the expression of SLCA5 and CAV1. The findings of this study suggest that curcumin could regulate FRGs in CRC and have the potential to be utilized as a therapeutic agent for treating CRC.<\/jats:p>","DOI":"10.1002\/cbf.3889","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T09:05:00Z","timestamp":1701162300000},"page":"1488-1502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Impact of curcumin on ferroptosis\u2010related genes in colorectal cancer: Insights from in\u2010silico and in\u2010vitro studies"],"prefix":"10.1002","volume":"41","author":[{"given":"Ali Ahmadizad","family":"Firouzjaei","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnology School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed 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