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Herein, we have summarized the current evidence regarding\n                    <jats:italic>H19<\/jats:italic>\n                    expression pattern and involvement in the developmental and pathological processes associated with the ovary and the placenta. The findings indicate that within the ovaries,\n                    <jats:italic>H19<\/jats:italic>\n                    is expressed in the antral and cystic atretic follicles as well as in the corpora lutea but absent in the primordial, primary, and secondary follicles. Its normal expression promotes the maturation of antral follicles and prevents their premature selection for the ovulatory journey while its aberrant induction promotes polycystic ovary syndrome development and ovarian cancer metastasis. In the placenta,\n                    <jats:italic>H19<\/jats:italic>\n                    is highly expressed in the cytotrophoblasts and extravillous trophoblasts but weakly expressed in the syncytiotrophoblast layer and potentially controls trophoblast cell fate decisions during placenta development. Abnormal expression of\n                    <jats:italic>H19<\/jats:italic>\n                    is observed in the placental villi of pregnancies affected by pre\u2010eclampsia and fetal growth restriction. Therefore, dysregulated\n                    <jats:italic>H19<\/jats:italic>\n                    is a candidate biomarker and therapeutic target for the mitigation of ovarian and placenta\u2010associated diseases.\n                  <\/jats:p>","DOI":"10.1002\/cbf.3907","type":"journal-article","created":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T13:08:50Z","timestamp":1704114530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long noncoding RNA H19 in ovarian biology and placenta development"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0667-890X","authenticated-orcid":false,"given":"Enoch Appiah","family":"Adu\u2010Gyamfi","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences University at Albany\u2014State University of New York Rensselaer New York USA"},{"name":"Cancer Research Center University at Albany\u2014State University of New 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