{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:23:41Z","timestamp":1790223821169,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alcoholic liver disease (ALD) is one of the most common health problems worldwide, especially in developing countries caused by chronic consumption of alcohol on a daily basis. The ALD spectrum is initiated with the early stages of alcoholic fatty liver (steatosis), progressing to alcoholic steatohepatitis, followed by the later stages of fibrosis and in some cases, cirrhosis and hepatocellular carcinoma (HCC). The Wnt\/\u03b2\u2010catenin signaling required for healthy liver development, function, and regeneration is found to be aberrated in ALD, attributed to its progression. This review is to elucidate the association of Wnt\/\u03b2\u2010catenin signaling with various stages of ALD progression. Alcohol causes downregulation of Wnt\/\u03b2\u2010catenin signaling components and thereby suppressing the pathway. Reports have been published that aberrated Wnt\/\u03b2\u2010catenin signaling, especially the absence of \u03b2\u2010catenin, results in decreased alcohol metabolism, causing steatosis followed by steatohepatitis via lipid accumulation, lipid peroxidation, liver injury, increased oxidative stress and apoptosis of hepatocytes, contributing to the advancement of ALD. Contrastingly, the progression of later stages of ALD like fibrosis and HCC depends on the increased activation of Wnt\/\u03b2\u2010catenin signaling and its components. Existing studies reveal the varied expression of Wnt\/\u03b2\u2010catenin signaling in ALD. However, the dual role of the Wnt\/\u03b2\u2010catenin pathway in earlier and later stages of ALD is not clear. Therefore, studies on the Wnt\/\u03b2\u2010catenin pathway and its components in various manifestations of ALD might provide insight in targeting the Wnt\/\u03b2\u2010catenin pathway in ALD treatment.<\/jats:p>","DOI":"10.1002\/cbf.3916","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T06:56:26Z","timestamp":1704696986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Molecular insights on intracellular Wnt\/\u03b2\u2010catenin signaling in alcoholic liver disease"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-884X","authenticated-orcid":false,"given":"Karthik","family":"Shree Harini","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Hepatology &amp; Molecular Medicine Lab, Saveetha Dental College Saveetha Institute of Medical and Technical Sciences (SIMATS)  Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5068-2383","authenticated-orcid":false,"given":"Devaraj","family":"Ezhilarasan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Hepatology &amp; Molecular Medicine Lab, Saveetha Dental College Saveetha Institute of Medical and Technical Sciences (SIMATS)  Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uthirappan","family":"Mani","sequence":"additional","affiliation":[{"name":"Animal House Division CSIR\u2010Central Leather Research Institute  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Alcohol, Culture and Society","author":"Patrick CH","year":"1952"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04002.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5772\/1440"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.137"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0145-y"},{"key":"e_1_2_11_7_1","volume-title":"Global Status Report on Alcohol and Health","author":"World Health Organization (WHO)","year":"2014"},{"key":"e_1_2_11_8_1","unstructured":"EASL. 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