{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:26:07Z","timestamp":1789413967075,"version":"build-2803163510"},"reference-count":118,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021JJ30491"],"award-info":[{"award-number":["2021JJ30491"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023JJ40492"],"award-info":[{"award-number":["2023JJ40492"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874375"],"award-info":[{"award-number":["81874375"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Over the past decade, the prevalence of diabetes has increased significantly worldwide, leading to an increase in vascular complications of diabetes (VCD), such as diabetic cardiomyopathy (DCM), diabetic nephropathy (DN), and diabetic retinopathy (DR). Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs), long Noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), play a key role in cellular processes, including the pathophysiology of diabetes and VCD via pyroptosis. ncRNAs (e.g., miR\u201017, lnc\u2010MEG3, and lnc\u2010KCNQ1OT1) can regulate pyroptosis in pancreatic \u03b2 cells. Some ncRNAs are involved in VCD progression. For example, miR\u201021, lnc\u2010KCNQ1OT1, lnc\u2010GAS5, and lnc\u2010MALAT1 were reported in DN and DCM, and lnc\u2010MIAT was identified in DCM and DR. Herein, this review aimed to summarize recent research findings related to ncRNAs\u2010mediated pyroptosis at the onset and progression of diabetes and VCD.<\/jats:p>","DOI":"10.1002\/cbf.3968","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T02:14:59Z","timestamp":1709604899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The role of ncRNAs\u2010mediated pyroptosis in diabetes and its vascular complications"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1427-8683","authenticated-orcid":false,"given":"Xinyao","family":"Feng","sequence":"first","affiliation":[{"name":"Hunan Key laboratory of Vascular Biology and Translational Medicine, Medical School Hunan University of Chinese Medicine  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxu","family":"Yang","sequence":"additional","affiliation":[{"name":"Hunan Key laboratory of Vascular Biology and Translational Medicine, Medical School Hunan University of Chinese Medicine  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yancheng","family":"Zhong","sequence":"additional","affiliation":[{"name":"Hunan Key laboratory of Vascular Biology and Translational Medicine, Medical School Hunan University of Chinese Medicine  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihua","family":"Cheng","sequence":"additional","affiliation":[{"name":"Hunan Key laboratory of Vascular Biology and Translational Medicine, Medical School Hunan University of Chinese Medicine  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71908-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.02.023"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12913"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-05078-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.89"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/14791641211058856"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0000599"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25020804"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225573"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20200032"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ncrna9040038"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz117"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.630032"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051835"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/358167a0"},{"issue":"3","key":"e_1_2_11_17_1","first-page":"113","article-title":"Pro\u2010inflammatory programmed cell death","volume":"9","author":"Cookson BT","year":"2001","journal-title":"TIM"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.768029"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04484-z"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S228654"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2023.112012"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15541"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.02.006"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.151"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2107314"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18590"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2021.167297"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9743280"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101534"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01306-2"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112863"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051516"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c03619"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.828240"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1132194"},{"issue":"1","key":"e_1_2_11_36_1","first-page":"87","article-title":"Expression of NLRP1 inflammasomes in myocardial tissue of diabetic rats","volume":"40","author":"Rong L","year":"2020","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.09.024"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.03.148"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-27825"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-020-00309-z"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01262"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01957"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600385"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060308-103103"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.744363"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2022.111798"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-021-00687-2"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.47021"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-02040-8"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.014"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2015.1020271"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0523-z"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.08.029"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S188396"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2018.11.019"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-3862"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110247"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-020-00275-6"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.99"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1195145"},{"key":"e_1_2_11_61_1","first-page":"3695","article-title":"Role of circulating exosomal miRNA\u20103976 in early diabetic retinopathy","volume":"18","author":"Yang S","year":"2023","journal-title":"Int J Nanomedicine"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-21-0227"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2018.01.010"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.09.139"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100179"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.08.031"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20210495"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2021.05.008"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00385"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03484-7"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2022.109152"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14510"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508372"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02492-6"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01522-y"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1029-4"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/5584894"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.06.026"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S385774"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.112464"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01401-7"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.02.065"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2022.153252"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108300"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2044734"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494576"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.08.022"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00053.2019"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S225791"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00403.2020"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.11898"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2022.146978"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2016.12.006"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/kjm2.12226"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-021-10164-6"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S298950"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103518"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2020.1831245"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/kjm2.12676"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.09.016"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13722"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b19-00901"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-023-04501-1"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15607-7"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905234106"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.430"},{"key":"e_1_2_11_107_1","article-title":"MiR\u2010200c\u20103p regulates pyroptosis by targeting SLC30A7 in diabetic retinopathy","volume":"41","author":"Li W","year":"2022","journal-title":"Hum Exp Toxicol"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103130"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12010146"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104661"},{"issue":"12","key":"e_1_2_11_111_1","first-page":"7015","article-title":"METTL14 regulates M6A methylation\u2010modified primary miR\u201019a to promote cardiovascular endothelial cell proliferation and invasion","volume":"24","author":"Zhang BY","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-006-0070-9"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11928"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36614-w"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-01807-0"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.05.016"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.02.014"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204745"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.806966"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.3968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:44:55Z","timestamp":1760276695000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.3968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":118,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/cbf.3968"],"URL":"https:\/\/doi.org\/10.1002\/cbf.3968","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"value":"0263-6484","type":"print"},{"value":"1099-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2024-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3968"}}