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Altered expression levels of the lncRNA NEAT1 have been reported in liver\u2010related disorders including cancer, fatty liver disease, liver fibrosis, viral hepatitis, and hepatic ischemia. lncRNA NEAT1 mostly acts as a competing endogenous RNA (ceRNA) to sponge various miRNAs (miRs) to regulate different functions. In regard to hepatic cancers, the elevated expression of NEAT1 has been reported to have a relation with the proliferation, migration, angiogenesis, apoptosis, as well as epithelial\u2010mesenchymal transition (EMT) of cancer cells. Furthermore, NEAT1 upregulation has contributed to the pathogenesis of other liver diseases such as fibrosis. In this review, we summarize and discuss the molecular mechanisms by which NEAT1 contributes to liver\u2010related disorders including acute liver failure, nonalcoholic fatty liver disease (NAFLD), liver fibrosis, and liver carcinoma, providing novel insights and introducing NEAT1 as a potential therapeutic target in these diseases.<\/jats:p>","DOI":"10.1002\/cbf.4006","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T02:00:08Z","timestamp":1713232808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["LncRNA NEAT1 in the pathogenesis of liver\u2010related diseases"],"prefix":"10.1002","volume":"42","author":[{"given":"Raed Obaid","family":"Saleh","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Techniques Al\u2010Maarif University College  Al\u2010Anbar Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan Taan","family":"Alkhafaji","sequence":"additional","affiliation":[{"name":"Cardiology Department, College of Medicine Al\u2010Ayen University Thi\u2010Qar Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-4931","authenticated-orcid":false,"given":"Jaafaru Sani","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Medical Analysis Department Tishk International University Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Genetics Jain (Deemed\u2010to\u2010be) University Bengaluru Karnataka India"},{"name":"Department of Allied Healthcare and Sciences Vivekananda Global University Jaipur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"School of Basic &amp; 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