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Hence, they are also called as proteinopathy diseases. Gender is considered as one of the risk factors in both diseases. Estrogens are widely accepted to be neuroprotective in several neurodegenerative disorders. Estrogens can be produced in the central nervous system, where they are called as neurosteroids. Estrogens mediate their neuroprotective action mainly through their actions on estrogen receptor alpha (ER\u03b1) and estrogen receptor beta (ER\u03b2). However, ER\u03b1 is mainly involved in the growth and development of the primary and secondary sexual organs in females. Hence, the activation of ER\u03b1 is associated with undesired side effects such as gynecomastia and increase in the risk of breast cancer, thromboembolism, and feminization. Therefore, selective activation of ER\u03b2 is often considered to be safer. In this review, we explore the role of ER\u03b2 in regulating the expression and functions of AD\u2010 and PD\u2010associated genes. Additionally, we discuss the association of these genes with the amyloid\u2010beta peptide (A\u03b2) and \u03b1\u2010synuclein mediated toxicity. Ultimately, we established a correlation between the importance of ER\u03b2 activation and the process underlying ER\u03b2\u2018s neuroprotective mechanisms in AD and PD.<\/jats:p>","DOI":"10.1002\/cbf.4014","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:33:58Z","timestamp":1713141238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Molecular insights into the potential effects of selective estrogen receptor \u03b2 agonists in Alzheimer's and Parkinson's diseases"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-1073","authenticated-orcid":false,"given":"Emdormi","family":"Rymbai","sequence":"first","affiliation":[{"name":"Department of Pharmacology, JSS College of Pharmacy JSS Academy of Higher Education &amp; Research Ooty Tamil Nadu 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