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Curcumin (CUR), a natural compound derived from turmeric, exerts beneficial effects on diabetes mellitus through its interaction with the nuclear factor kappa B (NF\u2010\u03baB) pathway. Research indicates that CUR targets inflammatory mediators in diabetes, including tumor necrosis factor \u03b1 (TNF\u2010\u03b1) and interleukin\u20106 (IL\u20106), by modulating the NF\u2010\u03baB signaling pathway. By reducing the expression of these inflammatory factors, CUR demonstrates protective effects in DM by improving pancreatic \u03b2\u2010cells function, normalizing inflammatory cytokines, reducing OS and enhancing insulin sensitivity. The findings reveal that CUR administration effectively lowered blood glucose elevation, reinstated diminished serum insulin levels, and enhanced body weight in Streptozotocin \u2010induced diabetic rats. CUR exerts its beneficial effects in management of diabetic complications through regulation of signaling pathways, such as calcium\u2013calmodulin (CaM)\u2010dependent protein kinase II (CaMKII), peroxisome proliferator\u2010activated receptor gamma (PPAR\u2010\u03b3), NF\u2010\u03baB, and transforming growth factor \u03b21 (TGFB1). Moreover, CUR reversed the heightened expression of inflammatory cytokines (TNF\u2010\u03b1, Interleukin\u20101 beta (IL\u20101\u03b2), IL\u20106) and chemokines like MCP\u20101 in diabetic specimens, vindicating its anti\u2010inflammatory potency in counteracting hyperglycemia\u2010induced alterations. CUR diminishes OS, avert structural kidney damage linked to diabetic nephropathy, and suppress NF\u2010\u03baB activity. Furthermore, CUR exhibited a protective effect against diabetic cardiomyopathy, lung injury, and diabetic gastroparesis. Conclusively, the study posits that CUR could potentially offer therapeutic benefits in relieving diabetic complications through its influence on the NF\u2010\u03baB pathway.<\/jats:p>","DOI":"10.1002\/cbf.4030","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T03:23:28Z","timestamp":1715225008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["NF\u2010\u03baB pathway as a molecular target for curcumin in diabetes mellitus treatment: Focusing on oxidative stress and inflammation"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0944-0320","authenticated-orcid":false,"given":"Mohammad Yasin","family":"Zamanian","sequence":"first","affiliation":[{"name":"Department of Physiology Hamadan University of Medical Sciences Hamadan Iran"},{"name":"Department of Pharmacology and Toxicology, School of Pharmacy Hamadan University of Medical Sciences 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