{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:13:29Z","timestamp":1790140409985,"version":"4.0.1"},"reference-count":114,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Previous studies suggested that central nervous system injury is often accompanied by the activation of Toll\u2010like receptor 4\/NF\u2010\u03baB pathway, which leads to the upregulation of proapoptotic gene expression, causes mitochondrial oxidative stress, and further aggravates the inflammatory response to induce cell apoptosis. Subsequent studies have shown that NF\u2010\u03baB and I\u03baB\u03b1 can directly act on mitochondria. Therefore, elucidation of the specific mechanisms of NF\u2010\u03baB and I\u03baB\u03b1 in mitochondria may help to discover new therapeutic targets for central nervous system injury. Recent studies have suggested that NF\u2010\u03baB (especially RelA) in mitochondria can inhibit mitochondrial respiration or DNA expression, leading to mitochondrial dysfunction. I\u03baB\u03b1 silencing will cause reactive oxygen species storm and initiate the mitochondrial apoptosis pathway. Other research results suggest that RelA can regulate mitochondrial respiration and energy metabolism balance by interacting with p53 and STAT3, thus initiating the mitochondrial protection mechanism. I\u03baB\u03b1 can also inhibit apoptosis in mitochondria by interacting with VDAC1 and other molecules. Regulating the biological role of NF\u2010\u03baB signaling pathway in mitochondria by targeting key proteins such as p53, STAT3, and VDAC1 may help maintain the balance of mitochondrial respiration and energy metabolism, thereby protecting nerve cells and reducing inflammatory storms and death caused by ischemia and hypoxia.<\/jats:p>","DOI":"10.1002\/cbf.4056","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T01:41:09Z","timestamp":1717033269000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Biological role of mitochondrial TLR4\u2010mediated NF\u2010\u03baB signaling pathway in central nervous system injury"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4983-6100","authenticated-orcid":false,"given":"Zhuochao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Ningbo Medical Center LiHuiLi Hospital The Affiliated LiHuiLi Hospital of Ningbo University Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9798-7782","authenticated-orcid":false,"given":"Ying","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Zhejiang University of Technology Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Ningbo Medical Center LiHuiLi Hospital The Affiliated LiHuiLi Hospital of Ningbo University Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Ningbo Medical Center LiHuiLi Hospital The Affiliated LiHuiLi Hospital of Ningbo University Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasonic Cixi Hospital of Traditional Chinese Medicine Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Ningbo Medical Center LiHuiLi Hospital The Affiliated LiHuiLi Hospital of Ningbo University Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Ningbo Medical Center LiHuiLi Hospital The Affiliated LiHuiLi Hospital of Ningbo University Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guomin","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ningbo Medical Center LiHuiLi Hospital The Affiliated LiHuiLi Hospital of Ningbo University Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Ningbo Institute of Innovation for Combined Medicine and Engineering, Ningbo Medical Center LiHuiLi Hospital The Affiliated LiHuiLi Hospital of Ningbo University Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1466-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051230"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110439"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.107"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.036946"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2592935"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10010021"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0092-22.2022"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.812774"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-16"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.585146"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-021-03481-0"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-021-02198-9"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3263446"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.803885"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117435"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01107"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111225"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.106030"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2020.1840035"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.436"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.06.002"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1538-9"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126399"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-1951"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-014-0075-5"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2022.05.121"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153411"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107634"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290045"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290210"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.02.021"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.624919"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00973-3"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400779"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203794"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S140526"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1368"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209995200"},{"issue":"21","key":"e_1_2_10_41_1","first-page":"7785","article-title":"Activation of nuclear factor kappaB through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: a brake to apoptosis in HeLa human carcinoma cells","volume":"61","author":"Bottero V","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4252"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20192101"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201488183"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404928200"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00154"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202201855RR"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005850200"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp305"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44708"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2016_3"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3116"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2015.07.002"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.574.2.10"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-01921-x"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.841646"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092820"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-1009-0"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311143"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010048"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2017.1416773"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2018.05.009"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/12050"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.29.20664"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.07.024"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.03.007"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23132"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S350109"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-014-0222-3"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2019.1676416"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8039"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14060"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9030207"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116681"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-222992"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.09.013"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23587"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117518"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1159\/000370031"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1700488"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1907-y"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03713-0"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.03.020"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9424582"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01107-9"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.09.012"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2306399120"},{"issue":"1","key":"e_1_2_10_88_1","first-page":"10","article-title":"High\u2010mobility group box 1, an endogenous ligand of toll\u2010like receptors 2 and 4, induces astroglial inflammation via nuclear factor kappa B pathway","volume":"78","author":"Al\u2010Ofi EA","year":"2019","journal-title":"Folia Morphol"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9478-6"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4665530"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1177\/17590914211051908"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl249"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14687"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23168972"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104814"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.114231"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.08.008"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.999061"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8807676"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3298400"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.07.001"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-023-03208-7"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35789-3"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-014-9567-7"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2020.12.008"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759091417745426"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114356"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8999899"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2020.148357"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2020.105704"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12289"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2020.04.004"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2324"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.03.007"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00072"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.4056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:18:46Z","timestamp":1760329126000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.4056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,29]]},"references-count":114,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/cbf.4056"],"URL":"https:\/\/doi.org\/10.1002\/cbf.4056","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"value":"0263-6484","type":"print"},{"value":"1099-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,29]]},"assertion":[{"value":"2023-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e4056"}}