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The goal of the current investigation was to examine the protective effects of p\u2010coumaric acid against the liver damage caused by KBrO<jats:sub>3<\/jats:sub>. The five groups of animals\u2010control, KBrO<jats:sub>3<\/jats:sub> (100\u2009mg\/kg bw), treatment with KBrO<jats:sub>3<\/jats:sub> along with Silymarin (100\u2009mg\/kg bw), KBrO<jats:sub>3,<\/jats:sub> followed by PCA (100\u2009mg\/bw, and 200\u2009mg\/kg bw) were randomly assigned to the animals. Mice were slaughtered, and blood and liver tissues were taken for assessment of the serum biochemical analysis for markers of liver function (alanine transaminase, aspartate transaminase, alkaline phosphatase, albumin, and protein), lipid markers and antioxidant markers (TBARS), glutathione peroxidase [GSH\u2010Px], glutathione (GSH), and markers of hepatic oxidative stress (CAT), (SOD), as well as histological H&amp;E stain, immunohistochemical stain iNOS, and COX\u20102 as markers of inflammatory cytokines. PCA protects against acute liver failure by preventing the augmentation of blood biochemical markers and lipid profiles. In mice liver tissues, KBrO<jats:sub>3<\/jats:sub> increases lipid indicators and depletes antioxidants, leading to an increase in JNK, ERK, and p38 phosphorylation. Additionally, PCA inhibited the production of pro\u2010inflammatory cytokines and reduced the histological alterations in KBrO<jats:sub>3<\/jats:sub>\u2010induced hepatotoxicity. Notably, PCA effectively mitigated KBrO<jats:sub>3<\/jats:sub>\u2010induced hepatic damage by obstructing the TNF\u2010\u03b1\/NF\u2010kB\u2010mediated inflammatory process signaling system. Additionally, in KBrO<jats:sub>3<\/jats:sub>\u2010induced mice, PCA increased the intensities of hepatic glutathione (GSH), SOD, GSH\u2010Px, catalase, and GSH activities. Collectively, we demonstrate the molecular evidence that PCA eliminated cellular inflammatory conditions, mitochondrial oxidative stress, and the TNF\u2010\u03b1\/NF\u2010\u03baB signaling process, thereby preventing KBrO<jats:sub>3<\/jats:sub>\u2010induced hepatocyte damage.<\/jats:p>","DOI":"10.1002\/cbf.4076","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T06:59:50Z","timestamp":1718780390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["p\u2010Coumaric acid pronounced protective effect against potassium bromate\u2010induced hepatic damage in Swiss albino mice"],"prefix":"10.1002","volume":"42","author":[{"given":"Selvaraj","family":"Nivetha","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology Annamalai University Annamalainagar India"},{"name":"Department of Biochemistry Government Arts College Paramakudi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumaraswami Radha Thayammal","family":"Asha","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Government Arts College Paramakudi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramani","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology Annamalai University Annamalainagar India"},{"name":"Department of Biochemistry Government Arts College for Women Krishnagiri India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raju","family":"Murali","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology Annamalai University Annamalainagar India"},{"name":"Department of Biochemistry Government Arts College for Women Krishnagiri India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6273-4136","authenticated-orcid":false,"given":"Ambothi","family":"Kanagalakshmi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology Annamalai University Annamalainagar India"},{"name":"Department of Biochemistry Government Arts College for Women Krishnagiri India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9056845"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.05.026"},{"issue":"1","key":"e_1_2_9_4_1","first-page":"126","article-title":"Potassium bromate\u2010induced kidney damage in rats and the effect of gum acacia thereon","volume":"10","author":"Ali BH","year":"2018","journal-title":"Am J Transl Res"},{"issue":"2","key":"e_1_2_9_5_1","first-page":"89","article-title":"Effect of rosmarinic acid on potassium bromate induced renal cortical oxidative stress and apoptosis in adult male albino rat","volume":"24","author":"Elgendy Hanan A.","year":"2020","journal-title":"Eur. 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